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10.1016/j.gene.2021.145496

http://scihub22266oqcxt.onion/10.1016/j.gene.2021.145496
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33588037!7880849!33588037
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suck abstract from ncbi


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pmid33588037      Gene 2021 ; 779 (ä): 145496
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  • Transmission dynamics of SARS-CoV-2 on the Diamond Princess uncovered using viral genome sequence analysis #MMPMID33588037
  • Hoshino K; Maeshiro T; Nishida N; Sugiyama M; Fujita J; Gojobori T; Mizokami M
  • Gene 2021[May]; 779 (ä): 145496 PMID33588037show ga
  • An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred aboard the Diamond Princess cruise ship between her January 20 departure and late February 2020. Here, we used phylodynamic analyses to investigate the transmission dynamics of SARS-CoV-2 during the outbreak. Using a Bayesian coalescent-based method, the estimated mean nucleotide substitution rate of 240 SARS-CoV-2 whole-genome sequences was approximately 7.13 x 10(-4) substitutions per site per year. Population dynamics and the effective reproductive number (R(e)) of SARS-CoV-2 infections were estimated using a Bayesian framework. The estimated origin of the outbreak was January 21, 2020. The infection spread substantially before quarantine on February 5. The R(e) peaked at 6.06 on February 4 and gradually declined to 1.51, suggesting that transmission continued slowly even after quarantine. These findings highlight the high transmissibility of SARS-CoV-2 and the need for effective measures to control outbreaks in confined settings.
  • |Bayes Theorem[MESH]
  • |COVID-19/*transmission[MESH]
  • |Disease Outbreaks/prevention & control[MESH]
  • |Humans[MESH]
  • |Phylogeny[MESH]
  • |Polymorphism, Single Nucleotide[MESH]
  • |Quarantine[MESH]
  • |RNA, Viral/*genetics[MESH]
  • |SARS-CoV-2/*classification/genetics/isolation & purification[MESH]
  • |Sequence Analysis, RNA[MESH]
  • |Ships[MESH]


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