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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Gene 2021 ; 779 (ä): 145496 Nephropedia Template TP
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Transmission dynamics of SARS-CoV-2 on the Diamond Princess uncovered using viral genome sequence analysis #MMPMID33588037
Hoshino K; Maeshiro T; Nishida N; Sugiyama M; Fujita J; Gojobori T; Mizokami M
Gene 2021[May]; 779 (ä): 145496 PMID33588037show ga
An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred aboard the Diamond Princess cruise ship between her January 20 departure and late February 2020. Here, we used phylodynamic analyses to investigate the transmission dynamics of SARS-CoV-2 during the outbreak. Using a Bayesian coalescent-based method, the estimated mean nucleotide substitution rate of 240 SARS-CoV-2 whole-genome sequences was approximately 7.13 x 10(-4) substitutions per site per year. Population dynamics and the effective reproductive number (R(e)) of SARS-CoV-2 infections were estimated using a Bayesian framework. The estimated origin of the outbreak was January 21, 2020. The infection spread substantially before quarantine on February 5. The R(e) peaked at 6.06 on February 4 and gradually declined to 1.51, suggesting that transmission continued slowly even after quarantine. These findings highlight the high transmissibility of SARS-CoV-2 and the need for effective measures to control outbreaks in confined settings.