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10.1093/bib/bbab027 http://scihub22266oqcxt.onion/10.1093/bib/bbab027 33587745!7929378!33587745     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2021 ; 22 (2): 1096-1105 Nephropedia Template TP {{tp|p=33587745|t=2021. Roles of host small RNAs in the evolution and host tropism of coronaviruses |pdf=|usr=}}{{33587745}} gab.com Text Roles of host small RNAs in the evolution and host tropism of coronaviruses JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33587745 #FOAvip Human coronaviruses (CoVs) can cause respiratory infection epidemics that sometimes expand into globally relevant pandemics. All human CoVs have sister strains isolated from animal hosts and seem to have an animal origin, yet the process of host jumping is largely unknown. RNA interference (RNAi) is an ancient mechanism in many eukaryotes to defend against viral infections through the hybridization of host endogenous small RNAs (miRNAs) with target sites in invading RNAs. Here, we developed a method to identify potential RNAi-sensitive sites in the viral genome and discovered that human-adapted coronavirus strains had deleted some of their sites targeted by miRNAs in human lungs when compared to their close zoonic relatives. We further confirmed using a phylogenetic analysis that the loss of RNAi-sensitive target sites could be a major driver of the host-jumping process, and adaptive mutations that lead to the loss-of-target might be as simple as point mutation. Up-to-date genomic data of severe acute respiratory syndrome coronavirus 2 and Middle-East respiratory syndromes-CoV strains demonstrate that the stress from host miRNA milieus sustained even after their epidemics in humans. Thus, this study illustrates a new mechanism about coronavirus to explain its host-jumping process and provides a novel avenue for pathogenesis research, epidemiological modeling, and development of drugs and vaccines against coronavirus, taking into consideration these findings. Twit Text FOAVip Roles of host small RNAs in the evolution and host tropism of coronaviruses ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=33587745 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33587745 #FOAvip English Wikipedia <ref>{{Cite pmid|33587745}}</ref> Roles of host small RNAs in the evolution and host tropism of coronaviruses #MMPMID33587745 Meng Q; Chu Y; Shao C; Chen J; Wang J; Gao Z; Yu J; Kang Y Brief Bioinform 2021[Mar]; 22 (2): 1096-1105 PMID33587745show ga Human coronaviruses (CoVs) can cause respiratory infection epidemics that sometimes expand into globally relevant pandemics. All human CoVs have sister strains isolated from animal hosts and seem to have an animal origin, yet the process of host jumping is largely unknown. RNA interference (RNAi) is an ancient mechanism in many eukaryotes to defend against viral infections through the hybridization of host endogenous small RNAs (miRNAs) with target sites in invading RNAs. Here, we developed a method to identify potential RNAi-sensitive sites in the viral genome and discovered that human-adapted coronavirus strains had deleted some of their sites targeted by miRNAs in human lungs when compared to their close zoonic relatives. We further confirmed using a phylogenetic analysis that the loss of RNAi-sensitive target sites could be a major driver of the host-jumping process, and adaptive mutations that lead to the loss-of-target might be as simple as point mutation. Up-to-date genomic data of severe acute respiratory syndrome coronavirus 2 and Middle-East respiratory syndromes-CoV strains demonstrate that the stress from host miRNA milieus sustained even after their epidemics in humans. Thus, this study illustrates a new mechanism about coronavirus to explain its host-jumping process and provides a novel avenue for pathogenesis research, epidemiological modeling, and development of drugs and vaccines against coronavirus, taking into consideration these findings. |*Biological Evolution[MESH] |*Host-Pathogen Interactions[MESH] |*Viral Tropism[MESH] |COVID-19/*virology[MESH] |Humans[MESH] |RNA/*physiology[MESH]Roles of host small RNAs in the evolution and host tropism of coronavi(epmc).pdf DeepDyve Pubget Overpricing