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10.1007/s11427-020-1893-9 http://scihub22266oqcxt.onion/10.1007/s11427-020-1893-9 33587268!7882856!33587268     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+China+Life+Sci 2021 ; 64 (7): 1062-1067 Nephropedia Template TP {{tp|p=33587268|t=2021. Making sense of spike D614G in SARS-CoV-2 transmission |pdf=|usr=}}{{33587268}} gab.com Text Making sense of spike D614G in SARS-CoV-2 transmission JO: Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33587268 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the current coronavirus disease 2019 (COVID-19) pandemic, has evolved to adapt to human host and transmission over the past 12 months. One prominent adaptive mutation is the asparagine-to-glycine substitution at amino acid position 614 in the viral spike protein (D614G), which has become dominant in the currently circulating virus strains. Since spike protein determines host ranges, tissue tropism, and pathogenesis through binding to the cellular receptor of angiotensin converting enzyme 2 (ACE2), the D614G mutation is hypothesized to enhance viral fitness in human host, leading to increased transmission during the global pandemic. Here we summarize the recent progress on the role of the D614G mutation in viral replication, pathogenesis, transmission, and vaccine and therapeutic antibody development. These findings underscore the importance in closely monitoring viral evolution and defining their functions to ensure countermeasure efficacy against newly emerging variants. Twit Text FOAVip Making sense of spike D614G in SARS-CoV-2 transmission ????Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33587268 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33587268 #FOAvip English Wikipedia <ref>{{Cite pmid|33587268}}</ref> Making sense of spike D614G in SARS-CoV-2 transmission #MMPMID33587268 Shi AC; Xie X Sci China Life Sci 2021[Jul]; 64 (7): 1062-1067 PMID33587268show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the current coronavirus disease 2019 (COVID-19) pandemic, has evolved to adapt to human host and transmission over the past 12 months. One prominent adaptive mutation is the asparagine-to-glycine substitution at amino acid position 614 in the viral spike protein (D614G), which has become dominant in the currently circulating virus strains. Since spike protein determines host ranges, tissue tropism, and pathogenesis through binding to the cellular receptor of angiotensin converting enzyme 2 (ACE2), the D614G mutation is hypothesized to enhance viral fitness in human host, leading to increased transmission during the global pandemic. Here we summarize the recent progress on the role of the D614G mutation in viral replication, pathogenesis, transmission, and vaccine and therapeutic antibody development. These findings underscore the importance in closely monitoring viral evolution and defining their functions to ensure countermeasure efficacy against newly emerging variants. |*Mutation[MESH] |*SARS-CoV-2[MESH] |Angiotensin-Converting Enzyme 2/chemistry[MESH] |Animals[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/*transmission[MESH] |Humans[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*genetics/physiology[MESH]Making sense of spike D614G in SARS-CoV-2 transmission (epmc).pdf DeepDyve Pubget Overpricing