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10.3389/fmed.2020.608804

http://scihub22266oqcxt.onion/10.3389/fmed.2020.608804
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suck abstract from ncbi


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pmid33585509      Front+Med+(Lausanne) 2020 ; 7 (ä): 608804
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  • Humoral and Cellular Response of Frontline Health Care Workers Infected by SARS-CoV-2 in Nice, France: A Prospective Single-Center Cohort Study #MMPMID33585509
  • Cremoni M; Ruetsch C; Zorzi K; Fernandez C; Boyer-Suavet S; Benzaken S; Demonchy E; Dellamonica J; Ichai C; Esnault V; Brglez V; Seitz-Polski B
  • Front Med (Lausanne) 2020[]; 7 (ä): 608804 PMID33585509show ga
  • Frontline health care workers (HCWs) have been particularly exposed to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) since the start of the pandemic but the clinical features and immune responses of those infected with SARS-CoV-2 have not been well described. In a prospective single center cohort study, we enrolled 196 frontline HCWs exposed to the SARS-Cov-2 and 60 patients with moderate and severe forms of the coronavirus disease 2019 (COVID-19). Serological tests and cytokines assay were performed to analyze SARS-CoV-2-specific humoral and cellular immunity. Of the 196 HCWs tested, 15% had specific antibodies against SARS-CoV-2 and 45% of seropositive HCWs were strictly asymptomatic. However, in comparison to moderate and severe forms, HCWs with mild or asymptomatic forms of COVID-19 showed lower specific IgA and IgG peaks, consistent with their mild symptoms, and a robust immune cellular response, illustrated by a high production of type I and II interferons. Further studies are needed to evaluate whether this interferon functional immune assay, routinely applicable, can be useful in predicting the risk of severe forms of COVID-19.
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