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10.1007/s13721-020-00279-y

http://scihub22266oqcxt.onion/10.1007/s13721-020-00279-y
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suck abstract from ncbi


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pmid33585155      Netw+Model+Anal+Health+Inform+Bioinform 2021 ; 10 (1): 8
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  • Exploring the active constituents of Oroxylum indicum in intervention of novel coronavirus (COVID-19) based on molecular docking method #MMPMID33585155
  • Shah S; Chaple D; Arora S; Yende S; Moharir K; Lohiya G
  • Netw Model Anal Health Inform Bioinform 2021[]; 10 (1): 8 PMID33585155show ga
  • The severe acute respiratory syndrome COVID-19 declared a global pandemic by WHO has become the present wellbeing worry to the whole world. There is an emergent need to search for possible medications. We report in this study a molecular docking study of eighteen Oroxylum indicum molecules with the main protease (M(pro)) responsible for the replication of SARS-CoV-2 virus. The outcome of their molecular simulation and ADMET properties reveal four potential inhibitors of the enzyme (Baicalein-7-O-diglucoside, Chrysin-7-O-glucuronide, Oroxindin and Scutellarein) with preference of ligand Chrysin-7-O-glucuronide that has the second highest binding energy (- 8.6 kcal/mol) and fully obeys the Lipinski's rule of five. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13721-020-00279-y.
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