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10.3389/fimmu.2020.621735

http://scihub22266oqcxt.onion/10.3389/fimmu.2020.621735
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33584720!7878381!33584720
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suck abstract from ncbi


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pmid33584720      Front+Immunol 2020 ; 11 (ä): 621735
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  • Infection Mechanism of SARS-COV-2 and Its Implication on the Nervous System #MMPMID33584720
  • Reza-Zaldivar EE; Hernandez-Sapiens MA; Minjarez B; Gomez-Pinedo U; Marquez-Aguirre AL; Mateos-Diaz JC; Matias-Guiu J; Canales-Aguirre AA
  • Front Immunol 2020[]; 11 (ä): 621735 PMID33584720show ga
  • In late December 2019, multiple atypical pneumonia cases resulted in severe acute respiratory syndrome caused by a pathogen identified as a novel coronavirus SARS-CoV-2. The most common coronavirus disease 2019 (COVID-19) symptoms are pneumonia, fever, dry cough, and fatigue. However, some neurological complications following SARS-CoV-2 infection include confusion, cerebrovascular diseases, ataxia, hypogeusia, hyposmia, neuralgia, and seizures. Indeed, a growing literature demonstrates that neurotropism is a common feature of coronaviruses; therefore, the infection mechanisms already described in other coronaviruses may also be applicable for SARS-CoV-2. Understanding the underlying pathogenetic mechanisms in the nervous system infection and the neurological involvement is essential to assess possible long-term neurological alteration of COVID-19. Here, we provide an overview of associated literature regarding possible routes of COVID-19 neuroinvasion, such as the trans-synapse-connected route in the olfactory pathway and peripheral nerve terminals and its neurological implications in the central nervous system.
  • |Animals[MESH]
  • |COVID-19/*virology[MESH]
  • |Humans[MESH]
  • |Nervous System/*virology[MESH]


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