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10.3389/fimmu.2020.613613 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.613613 33584697!7876066!33584697     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 613613 Nephropedia Template TP {{tp|p=33584697|t=2020. Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective |pdf=|usr=}}{{33584697}} gab.com Text Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33584697 #FOAvip Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes, once activated, promote caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, interleukin (IL)-1beta and IL-18, leading to pyroptosis. Current advances in inflammasome research support their involvement in the development of chronic inflammatory disorders in contrast to their role in regulating innate immunity. Cannabis (marijuana) is a natural product obtained from the Cannabis sativa plant, and pharmacologically active ingredients of the plant are referred to as cannabinoids. Cannabinoids and cannabis extracts have recently emerged as promising novel drugs for chronic medical conditions. Growing evidence indicates the potent anti-inflammatory potential of cannabinoids, especially Delta(9)-tetrahydrocannabinol (Delta(9)-THC), cannabidiol (CBD), and synthetic cannabinoids; however, the mechanisms remain unclear. Several attempts have been made to decipher the role of cannabinoids in modulating inflammasome signaling in the etiology of chronic inflammatory diseases. In this review, we discuss recently published evidence on the effect of cannabinoids on inflammasome signaling. We also discuss the contribution of various cannabinoids in human diseases concerning inflammasome regulation. Lastly, in the milieu of coronavirus disease-2019 (COVID-19) pandemic, we confer available evidence linking inflammasome activation to the pathophysiology of COVID-19 suggesting overall, the importance of cannabinoids as possible drugs to target inflammasome activation in or to support the treatment of a variety of human disorders including COVID-19. Twit Text FOAVip Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33584697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33584697 #FOAvip English Wikipedia <ref>{{Cite pmid|33584697}}</ref> Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective #MMPMID33584697 Suryavanshi SV; Kovalchuk I; Kovalchuk O Front Immunol 2020[]; 11 (ä): 613613 PMID33584697show ga Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes, once activated, promote caspase-1-mediated maturation and secretion of pro-inflammatory cytokines, interleukin (IL)-1beta and IL-18, leading to pyroptosis. Current advances in inflammasome research support their involvement in the development of chronic inflammatory disorders in contrast to their role in regulating innate immunity. Cannabis (marijuana) is a natural product obtained from the Cannabis sativa plant, and pharmacologically active ingredients of the plant are referred to as cannabinoids. Cannabinoids and cannabis extracts have recently emerged as promising novel drugs for chronic medical conditions. Growing evidence indicates the potent anti-inflammatory potential of cannabinoids, especially Delta(9)-tetrahydrocannabinol (Delta(9)-THC), cannabidiol (CBD), and synthetic cannabinoids; however, the mechanisms remain unclear. Several attempts have been made to decipher the role of cannabinoids in modulating inflammasome signaling in the etiology of chronic inflammatory diseases. In this review, we discuss recently published evidence on the effect of cannabinoids on inflammasome signaling. We also discuss the contribution of various cannabinoids in human diseases concerning inflammasome regulation. Lastly, in the milieu of coronavirus disease-2019 (COVID-19) pandemic, we confer available evidence linking inflammasome activation to the pathophysiology of COVID-19 suggesting overall, the importance of cannabinoids as possible drugs to target inflammasome activation in or to support the treatment of a variety of human disorders including COVID-19. |Anti-Inflammatory Agents/*pharmacology[MESH] |COVID-19/*immunology[MESH] |Cannabinoids/*pharmacology[MESH] |Humans[MESH] |Inflammasomes/*drug effects/*immunology[MESH]Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Pe(epmc).pdf DeepDyve Pubget Overpricing