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10.3389/fphar.2020.621054

http://scihub22266oqcxt.onion/10.3389/fphar.2020.621054
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suck abstract from ncbi


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pmid33584306      Front+Pharmacol 2020 ; 11 (ä): 621054
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  • HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons #MMPMID33584306
  • Poloznikov AA; Nersisyan SA; Hushpulian DM; Kazakov EH; Tonevitsky AG; Kazakov SV; Vechorko VI; Nikulin SV; Makarova JA; Gazaryan IG
  • Front Pharmacol 2020[]; 11 (ä): 621054 PMID33584306show ga
  • The review analyzes the potential advantages and problems associated with using HIF prolyl hydroxylase inhibitors as a treatment for COVID-19. HIF prolyl hydroxylase inhibitors are known to boost endogenous erythropoietin (Epo) and activate erythropoiesis by stabilizing and activating the hypoxia inducible factor (HIF). Recombinant Epo treatment has anti-inflammatory and healing properties, and thus, very likely, will be beneficial for moderate to severe cases of COVID-19. However, HIF PHD inhibition may have a significantly broader effect, in addition to stimulating the endogenous Epo production. The analysis of HIF target genes reveals that some HIF-targets, such as furin, could play a negative role with respect to viral entry. On the other hand, HIF prolyl hydroxylase inhibitors counteract ferroptosis, the process recently implicated in vessel damage during the later stages of COVID-19. Therefore, HIF prolyl hydroxylase inhibitors may serve as a promising treatment of COVID-19 complications, but they are unlikely to aid in the prevention of the initial stages of infection.
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