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10.1007/s00705-021-04968-5

http://scihub22266oqcxt.onion/10.1007/s00705-021-04968-5
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33582855!7882042!33582855
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suck abstract from ncbi


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pmid33582855      Arch+Virol 2021 ; 166 (4): 1015-1033
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  • Viral mouse models used to study multiple sclerosis: past and present #MMPMID33582855
  • Libbey JE; Fujinami RS
  • Arch Virol 2021[Apr]; 166 (4): 1015-1033 PMID33582855show ga
  • Multiple sclerosis (MS) is a common inflammatory demyelinating disease of the central nervous system. Although the etiology of MS is unknown, genetics and environmental factors, such as infections, play a role. Viral infections of mice have been used as model systems to study this demyelinating disease of humans. Three viruses that have long been studied in this capacity are Theiler's murine encephalomyelitis virus, mouse hepatitis virus, and Semliki Forest virus. This review describes the viruses themselves, the infection process, the disease caused by infection and its accompanying pathology, and the model systems and their usefulness in studying MS.
  • |*Disease Models, Animal[MESH]
  • |Animals[MESH]
  • |Central Nervous System/pathology/physiology/virology[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |Multiple Sclerosis/immunology/*pathology/physiopathology/*virology[MESH]
  • |Murine hepatitis virus/pathogenicity/physiology[MESH]
  • |RNA Virus Infections/immunology/*pathology/physiopathology/*virology[MESH]
  • |Semliki forest virus/pathogenicity/physiology[MESH]


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