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10.1016/j.drudis.2021.02.004 http://scihub22266oqcxt.onion/10.1016/j.drudis.2021.02.004 33581321!ä!33581321       Drug+Discov+Today 2021 ; 26 (5): 1302-1310 Nephropedia Template TP {{tp|p=33581321|t=2021. A new horizon for the old antibacterial drug clofoctol |pdf=|usr=}}{{33581321}} gab.com Text A new horizon for the old antibacterial drug clofoctol JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=33581321 #FOAvip The synthetic antibacterial drug clofoctol (CFT) has long been used to treat respiratory tract infections in Europe. In recent years, the drug was found to target two biologically important proteins, the Cdc7/Dbf4 protein kinase complex and the mRNA-binding protein cold shock domain containing E1 (CSDE1), also known as upstream-of-N-Ras protein (UNR). These interactions are at the origin of the antitumor activity of CFT, recently evidenced in prostate cancer and neuroglioma. Drug-protein binding models provide a structural basis to guide the design of more potent anticancer compounds. A renewed interest in CFT can be anticipated for the treatment of cancers, and possibly Coronavirus 2019 (COVID-19). Twit Text FOAVip A new horizon for the old antibacterial drug clofoctol ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=33581321 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33581321 #FOAvip English Wikipedia <ref>{{Cite pmid|33581321}}</ref> A new horizon for the old antibacterial drug clofoctol #MMPMID33581321 Bailly C; Vergoten G Drug Discov Today 2021[May]; 26 (5): 1302-1310 PMID33581321show ga The synthetic antibacterial drug clofoctol (CFT) has long been used to treat respiratory tract infections in Europe. In recent years, the drug was found to target two biologically important proteins, the Cdc7/Dbf4 protein kinase complex and the mRNA-binding protein cold shock domain containing E1 (CSDE1), also known as upstream-of-N-Ras protein (UNR). These interactions are at the origin of the antitumor activity of CFT, recently evidenced in prostate cancer and neuroglioma. Drug-protein binding models provide a structural basis to guide the design of more potent anticancer compounds. A renewed interest in CFT can be anticipated for the treatment of cancers, and possibly Coronavirus 2019 (COVID-19). |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |Animals[MESH] |Anti-Bacterial Agents/adverse effects/*therapeutic use[MESH] |Antineoplastic Agents/adverse effects/*therapeutic use[MESH] |Antiviral Agents/adverse effects/*therapeutic use[MESH] |COVID-19/metabolism/virology[MESH] |Cell Cycle Proteins/metabolism[MESH] |Chlorobenzenes[MESH] |Cresols/adverse effects/therapeutic use[MESH] |DNA-Binding Proteins/metabolism[MESH] |Humans[MESH] |Neoplasms/*drug therapy/metabolism/pathology[MESH] |Protein Serine-Threonine Kinases/metabolism[MESH]A new horizon for the old antibacterial drug clofoctol (epmc).pdf DeepDyve Pubget Overpricing