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10.1093/infdis/jiab082

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33580259!7928763!33580259
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suck abstract from ncbi


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pmid33580259      J+Infect+Dis 2021 ; 223 (10): 1666-1670
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  • S-Variant SARS-CoV-2 Lineage B1 1 7 Is Associated With Significantly Higher Viral Load in Samples Tested by TaqPath Polymerase Chain Reaction #MMPMID33580259
  • Kidd M; Richter A; Best A; Cumley N; Mirza J; Percival B; Mayhew M; Megram O; Ashford F; White T; Moles-Garcia E; Crawford L; Bosworth A; Atabani SF; Plant T; McNally A
  • J Infect Dis 2021[May]; 223 (10): 1666-1670 PMID33580259show ga
  • A SARS-CoV-2 variant B1.1.7 containing mutation Delta69/70 has spread rapidly in the United Kingdom and shows an identifiable profile in ThermoFisher TaqPath RT-qPCR, S gene target failure (SGTF). We analyzed recent test data for trends and significance. Linked cycle threshold (Ct) values for respiratory samples showed that a low Ct for ORF1ab and N were clearly associated with SGTF. Significantly more SGTF samples had higher inferred viral loads between 1x107 and 1x108. Our conclusion is that patients whose samples exhibit the SGTF profile are more likely to have high viral loads, which may explain higher infectivity and rapidity of spread.
  • |*Viral Load[MESH]
  • |COVID-19/epidemiology/*virology[MESH]
  • |Humans[MESH]
  • |Linear Models[MESH]
  • |Polymerase Chain Reaction/*methods/standards[MESH]
  • |SARS-CoV-2/classification/genetics/*physiology[MESH]


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