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suck abstract from ncbi


10.1038/s42003-021-01743-9

http://scihub22266oqcxt.onion/10.1038/s42003-021-01743-9
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33580175!7881038!33580175
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suck abstract from ncbi

pmid33580175      Commun+Biol 2021 ; 4 (1): 225
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  • Immunoreactive peptide maps of SARS-CoV-2 #MMPMID33580175
  • Mishra N; Huang X; Joshi S; Guo C; Ng J; Thakkar R; Wu Y; Dong X; Li Q; Pinapati RS; Sullivan E; Caciula A; Tokarz R; Briese T; Lu J; Lipkin WI
  • Commun Biol 2021[Feb]; 4 (1): 225 PMID33580175show ga
  • Serodiagnosis of SARS-CoV-2 infection is impeded by immunological cross-reactivity among the human coronaviruses (HCoVs): SARS-CoV-2, SARS-CoV-1, MERS-CoV, OC43, 229E, HKU1, and NL63. Here we report the identification of humoral immune responses to SARS-CoV-2 peptides that may enable discrimination between exposure to SARS-CoV-2 and other HCoVs. We used a high-density peptide microarray and plasma samples collected at two time points from 50 subjects with SARS-CoV-2 infection confirmed by qPCR, samples collected in 2004-2005 from 11 subjects with IgG antibodies to SARS-CoV-1, 11 subjects with IgG antibodies to other seasonal human coronaviruses (HCoV), and 10 healthy human subjects. Through statistical modeling with linear regression and multidimensional scaling we identified specific peptides that were reassembled to identify 29 linear SARS-CoV-2 epitopes that were immunoreactive with plasma from individuals who had asymptomatic, mild or severe SARS-CoV-2 infections. Larger studies will be required to determine whether these peptides may be useful in serodiagnostics.
  • |*Peptide Mapping[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |COVID-19/blood/*immunology/*virology[MESH]
  • |Chiroptera[MESH]
  • |Epitopes/immunology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/metabolism[MESH]
  • |Peptides/chemistry/*immunology[MESH]
  • |Proteome/metabolism[MESH]


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