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10.1038/s42003-021-01736-8

http://scihub22266oqcxt.onion/10.1038/s42003-021-01736-8
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33580154!7881012!33580154
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suck abstract from ncbi


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pmid33580154      Commun+Biol 2021 ; 4 (1): 197
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  • Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection #MMPMID33580154
  • Karoyan P; Vieillard V; Gomez-Morales L; Odile E; Guihot A; Luyt CE; Denis A; Grondin P; Lequin O
  • Commun Biol 2021[Feb]; 4 (1): 197 PMID33580154show ga
  • In light of the recent accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral spike glycoprotein to human Angiotensin Converting Enzyme 2 (hACE2) receptor plays a central role in cell entry. We designed a series of peptides mimicking the N-terminal helix of hACE2 protein which contains most of the contacting residues at the binding site, exhibiting a high helical folding propensity in aqueous solution. Our best peptide-mimics are able to block SARS-CoV-2 human pulmonary cell infection with an inhibitory concentration (IC(50)) in the nanomolar range upon binding to the virus spike protein with high affinity. These first-in-class blocking peptide mimics represent powerful tools that might be used in prophylactic and therapeutic approaches to fight the coronavirus disease 2019 (COVID-19).
  • |Amino Acid Sequence[MESH]
  • |Angiotensin-Converting Enzyme 2/*chemistry[MESH]
  • |COVID-19/*virology[MESH]
  • |Cell Line[MESH]
  • |Circular Dichroism[MESH]
  • |Humans[MESH]
  • |Peptides/chemical synthesis/chemistry/metabolism/*pharmacology[MESH]
  • |Protein Binding/drug effects[MESH]
  • |Protein Structure, Secondary[MESH]
  • |SARS-CoV-2/*physiology[MESH]
  • |Spike Glycoprotein, Coronavirus/metabolism[MESH]


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