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10.1073/pnas.2022586118 http://scihub22266oqcxt.onion/10.1073/pnas.2022586118 33579792!7936381!33579792     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (9): ä Nephropedia Template TP {{tp|p=33579792|t=2021. The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 |pdf=|usr=}}{{33579792}} gab.com Text The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=33579792 #FOAvip The majority of currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses have mutant spike glycoproteins that contain the D614G substitution. Several studies have suggested that spikes with this substitution are associated with higher virus infectivity. We use cryo-electron microscopy to compare G614 and D614 spikes and show that the G614 mutant spike adopts a range of more open conformations that may facilitate binding to the SARS-CoV-2 receptor, ACE2, and the subsequent structural rearrangements required for viral membrane fusion. Twit Text FOAVip The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=33579792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33579792 #FOAvip English Wikipedia <ref>{{Cite pmid|33579792}}</ref> The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2 #MMPMID33579792 Benton DJ; Wrobel AG; Roustan C; Borg A; Xu P; Martin SR; Rosenthal PB; Skehel JJ; Gamblin SJ Proc Natl Acad Sci U S A 2021[Mar]; 118 (9): ä PMID33579792show ga The majority of currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses have mutant spike glycoproteins that contain the D614G substitution. Several studies have suggested that spikes with this substitution are associated with higher virus infectivity. We use cryo-electron microscopy to compare G614 and D614 spikes and show that the G614 mutant spike adopts a range of more open conformations that may facilitate binding to the SARS-CoV-2 receptor, ACE2, and the subsequent structural rearrangements required for viral membrane fusion. |COVID-19/*virology[MESH] |Cryoelectron Microscopy[MESH] |Humans[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*chemistry/genetics[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/genetics[MESH]The effect of the D614G substitution on the structure of the spike gly(epmc).pdf DeepDyve Pubget Overpricing