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10.4049/jimmunol.2001327 http://scihub22266oqcxt.onion/10.4049/jimmunol.2001327 33579725!ä!33579725 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2021 ; 206 (7): 1597-1608 Nephropedia Template TP {{tp|p=33579725|t=2021. The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression |pdf=|usr=}}{{33579725}} gab.com Text The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33579725 #FOAvip Coronavirus disease 2019 (COVID-19) is associated with immune dysregulation and cytokine storm. Exploring the immune-inflammatory characteristics of COVID-19 patients is essential to reveal pathogenesis and predict progression. In this study, COVID-19 patients showed decreased CD3(+), CD4(+), and CD8(+) T cells but increased neutrophils in circulation, exhibiting upregulated neutrophil-to-lymphocyte and neutrophil-to-CD8(+) T cell ratio. IL-6, TNF-alpha, IL-1beta, IL-18, IL-12/IL-23p40, IL-10, Tim-3, IL-8, neutrophil extracellular trap-related proteinase 3, and S100A8/A9 were elevated, whereas IFN-gamma and C-type lectin domain family 9 member A (clec9A) were decreased in COVID-19 patients compared with healthy controls. When compared with influenza patients, the expressions of TNF-alpha, IL-18, IL-12/IL-23p40, IL-8, S100A8/A9 and Tim-3 were significantly increased in critical COVID-19 patients, and carcinoembryonic Ag, IL-8, and S100A8/A9 could serve as clinically available hematologic indexes for identifying COVID-19 from influenza. Moreover, IL-6, IL-8, IL-1beta, TNF-alpha, proteinase 3, and S100A8/A9 were increased in bronchoalveolar lavage fluid of severe/critical patients compared with moderate patients, despite decreased CD4(+) T cells, CD8(+) T cells, B cells, and NK cells. Interestingly, bronchoalveolar IL-6, carcinoembryonic Ag, IL-8, S100A8/A9, and proteinase 3 were found to be predictive of COVID-19 severity and may serve as potential biomarkers for predicting COVID-19 progression and potential targets in therapeutic intervention of COVID-19. Twit Text FOAVip The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33579725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33579725 #FOAvip English Wikipedia <ref>{{Cite pmid|33579725}}</ref> The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression #MMPMID33579725 Huang W; Li M; Luo G; Wu X; Su B; Zhao L; Zhang S; Chen X; Jia M; Zhu J; Su W; Zhang D J Immunol 2021[Apr]; 206 (7): 1597-1608 PMID33579725show ga Coronavirus disease 2019 (COVID-19) is associated with immune dysregulation and cytokine storm. Exploring the immune-inflammatory characteristics of COVID-19 patients is essential to reveal pathogenesis and predict progression. In this study, COVID-19 patients showed decreased CD3(+), CD4(+), and CD8(+) T cells but increased neutrophils in circulation, exhibiting upregulated neutrophil-to-lymphocyte and neutrophil-to-CD8(+) T cell ratio. IL-6, TNF-alpha, IL-1beta, IL-18, IL-12/IL-23p40, IL-10, Tim-3, IL-8, neutrophil extracellular trap-related proteinase 3, and S100A8/A9 were elevated, whereas IFN-gamma and C-type lectin domain family 9 member A (clec9A) were decreased in COVID-19 patients compared with healthy controls. When compared with influenza patients, the expressions of TNF-alpha, IL-18, IL-12/IL-23p40, IL-8, S100A8/A9 and Tim-3 were significantly increased in critical COVID-19 patients, and carcinoembryonic Ag, IL-8, and S100A8/A9 could serve as clinically available hematologic indexes for identifying COVID-19 from influenza. Moreover, IL-6, IL-8, IL-1beta, TNF-alpha, proteinase 3, and S100A8/A9 were increased in bronchoalveolar lavage fluid of severe/critical patients compared with moderate patients, despite decreased CD4(+) T cells, CD8(+) T cells, B cells, and NK cells. Interestingly, bronchoalveolar IL-6, carcinoembryonic Ag, IL-8, S100A8/A9, and proteinase 3 were found to be predictive of COVID-19 severity and may serve as potential biomarkers for predicting COVID-19 progression and potential targets in therapeutic intervention of COVID-19. |*COVID-19/blood/immunology[MESH] |*Inflammation Mediators/blood/immunology[MESH] |*SARS-CoV-2/immunology/metabolism[MESH] |*Severity of Illness Index[MESH] |Aged[MESH] |Calgranulin A/blood/immunology[MESH] |Calgranulin B/blood/immunology[MESH] |Cytokines/blood/immunology[MESH] |Disease Progression[MESH] |Female[MESH] |Hepatitis A Virus Cellular Receptor 2/blood/immunology[MESH] |Humans[MESH] |Leukocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Myeloblastin/blood/immunology[MESH]The Inflammatory Factors Associated with Disease Severity to Predict C(epmc).pdf DeepDyve Pubget Overpricing