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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cells 2021 ; 10 (2): ä Nephropedia Template TP
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Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19 #MMPMID33578631
Flores-Pliego A; Miranda J; Vega-Torreblanca S; Valdespino-Vazquez Y; Helguera-Repetto C; Espejel-Nunez A; Borboa-Olivares H; Espino Y Sosa S; Mateu-Rogell P; Leon-Juarez M; Ramirez-Santes V; Cardona-Perez A; Villegas-Mota I; Torres-Torres J; Juarez-Reyes A; Rizo-Pica T; Gonzalez RO; Gonzalez-Mariscal L; Estrada-Gutierrez G
Cells 2021[Feb]; 10 (2): ä PMID33578631show ga
Clinical manifestations of coronavirus disease 2019 (COVID-19) in pregnant women are diverse, and little is known of the impact of the disease on placental physiology. Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been detected in the human placenta, and its binding receptor ACE2 is present in a variety of placental cells, including endothelium. Here, we analyze the impact of COVID-19 in placental endothelium, studying by immunofluorescence the expression of von Willebrand factor (vWf), claudin-5, and vascular endothelial (VE) cadherin in the decidua and chorionic villi of placentas from women with mild and severe COVID-19 in comparison to healthy controls. Our results indicate that: (1) vWf expression increases in the endothelium of decidua and chorionic villi of placentas derived from women with COVID-19, being higher in severe cases; (2) Claudin-5 and VE-cadherin expression decrease in the decidua and chorionic villus of placentas from women with severe COVID-19 but not in those with mild disease. Placental histological analysis reveals thrombosis, infarcts, and vascular wall remodeling, confirming the deleterious effect of COVID-19 on placental vessels. Together, these results suggest that placentas from women with COVID-19 have a condition of leaky endothelium and thrombosis, which is sensitive to disease severity.