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10.1016/j.ijid.2021.02.014

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.02.014
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33578014!7872854!33578014
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suck abstract from ncbi


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pmid33578014      Int+J+Infect+Dis 2021 ; 105 (ä): 598-605
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  • Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico #MMPMID33578014
  • Lima-Morales R; Mendez-Hernandez P; Flores YN; Osorno-Romero P; Sancho-Hernandez CR; Cuecuecha-Rugerio E; Nava-Zamora A; Hernandez-Galdamez DR; Romo-Duenas DK; Salmeron J
  • Int J Infect Dis 2021[Apr]; 105 (ä): 598-605 PMID33578014show ga
  • OBJECTIVE: There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid ("TNR4" therapy) to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. DESIGN AND METHODS: A comparative effectiveness study was performed among 768 confirmed SARS-CoV-2 cases aged 18-80 years, who received ambulatory care at the Ministry of Health of Tlaxcala. A total of 481 cases received the TNR4 therapy, while 287 received another treatment (comparison group). All participants received home visits and/or phone calls for clinical evaluation during the 14 days after enrollment. RESULTS: Nearly 85% of cases who received the TNR4 recovered within 14 days compared to 59% in the comparison group. The likelihood of recovery within 14 days was 3.4 times greater among the TNR4 group than in the comparison group. Patients treated with TNR4 had a 75% and 81% lower risk of being hospitalized or death, respectively, than the comparison group. CONCLUSIONS: TNR4 therapy improved recovery and prevented the risk of hospitalization and death among ambulatory COVID-19 cases.
  • |*COVID-19 Drug Treatment[MESH]
  • |Acetates/*therapeutic use[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Aspirin/*therapeutic use[MESH]
  • |Azithromycin/*therapeutic use[MESH]
  • |Cyclopropanes/*therapeutic use[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Ivermectin/*therapeutic use[MESH]
  • |Male[MESH]
  • |Mexico[MESH]
  • |Middle Aged[MESH]
  • |Quinolines/*therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Sulfides/*therapeutic use[MESH]
  • |Treatment Outcome[MESH]


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