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10.1016/j.cell.2021.01.035 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.01.035 33577765!7834972!33577765     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (5): 1188-1200.e19 Nephropedia Template TP {{tp|p=33577765|t=2021. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection |pdf=|usr=}}{{33577765}} gab.com Text Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33577765 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic. Twit Text FOAVip Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33577765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33577765 #FOAvip English Wikipedia <ref>{{Cite pmid|33577765}}</ref> Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection #MMPMID33577765 Brouwer PJM; Brinkkemper M; Maisonnasse P; Dereuddre-Bosquet N; Grobben M; Claireaux M; de Gast M; Marlin R; Chesnais V; Diry S; Allen JD; Watanabe Y; Giezen JM; Kerster G; Turner HL; van der Straten K; van der Linden CA; Aldon Y; Naninck T; Bontjer I; Burger JA; Poniman M; Mykytyn AZ; Okba NMA; Schermer EE; van Breemen MJ; Ravichandran R; Caniels TG; van Schooten J; Kahlaoui N; Contreras V; Lemaitre J; Chapon C; Fang RHT; Villaudy J; Sliepen K; van der Velden YU; Haagmans BL; de Bree GJ; Ginoux E; Ward AB; Crispin M; King NP; van der Werf S; van Gils MJ; Le Grand R; Sanders RW Cell 2021[Mar]; 184 (5): 1188-1200.e19 PMID33577765show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic. |*Macaca fascicularis[MESH] |Animals[MESH] |Antibodies, Neutralizing[MESH] |B-Lymphocytes/immunology[MESH] |COVID-19 Vaccines/*administration & dosage/*immunology[MESH] |COVID-19/immunology/prevention & control[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Models, Animal[MESH] |Nanoparticles/administration & dosage[MESH] |Rabbits[MESH] |SARS-CoV-2/physiology[MESH] |Spike Glycoprotein, Coronavirus/blood/*chemistry[MESH] |T-Lymphocytes/immunology[MESH]Two-component spike nanoparticle vaccine protects macaques from SARS-C(epmc).pdf DeepDyve Pubget Overpricing