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10.1016/j.immuni.2021.01.017 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.01.017 33577760!7846242!33577760     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33577760&cmd=llinks): Failed to open stream: HTTP request failed! 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Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity |pdf=|usr=}}{{33577760}} gab.com Text Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33577760 #FOAvip The emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity, mortality, and societal disruption. A better understanding of virus-host interactions may potentiate therapeutic insights toward limiting this infection. Here we investigated the dynamics of the systemic response to SARS-CoV-2 in hamsters by histological analysis and transcriptional profiling. Infection resulted in consistently high levels of virus in the upper and lower respiratory tracts and sporadic occurrence in other distal tissues. A longitudinal cohort revealed a wave of inflammation, including a type I interferon (IFN-I) response, that was evident in all tissues regardless of viral presence but was insufficient to prevent disease progression. Bolstering the antiviral response with intranasal administration of recombinant IFN-I reduced viral disease, prevented transmission, and lowered inflammation in vivo. This study defines the systemic host response to SARS-CoV-2 infection and supports use of intranasal IFN-I as an effective means of early treatment. Twit Text FOAVip Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33577760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33577760 #FOAvip English Wikipedia <ref>{{Cite pmid|33577760}}</ref> Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity #MMPMID33577760 Hoagland DA; Moller R; Uhl SA; Oishi K; Frere J; Golynker I; Horiuchi S; Panis M; Blanco-Melo D; Sachs D; Arkun K; Lim JK; tenOever BR Immunity 2021[Mar]; 54 (3): 557-570.e5 PMID33577760show ga The emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant global morbidity, mortality, and societal disruption. A better understanding of virus-host interactions may potentiate therapeutic insights toward limiting this infection. Here we investigated the dynamics of the systemic response to SARS-CoV-2 in hamsters by histological analysis and transcriptional profiling. Infection resulted in consistently high levels of virus in the upper and lower respiratory tracts and sporadic occurrence in other distal tissues. A longitudinal cohort revealed a wave of inflammation, including a type I interferon (IFN-I) response, that was evident in all tissues regardless of viral presence but was insufficient to prevent disease progression. Bolstering the antiviral response with intranasal administration of recombinant IFN-I reduced viral disease, prevented transmission, and lowered inflammation in vivo. This study defines the systemic host response to SARS-CoV-2 infection and supports use of intranasal IFN-I as an effective means of early treatment. |*Host-Pathogen Interactions/immunology[MESH] |Animals[MESH] |Biopsy[MESH] |COVID-19/genetics/immunology/*metabolism/*virology[MESH] |Cricetinae[MESH] |Cytokines/genetics/metabolism[MESH] |Disease Models, Animal[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Interferon Type I/genetics/*metabolism[MESH] |Lung/immunology/metabolism/pathology/virology[MESH] |Organ Specificity/immunology[MESH] |SARS-CoV-2/*physiology[MESH] |Virulence[MESH]Leveraging the antiviral type I interferon system as a first line of d(epmc).pdf DeepDyve Pubget Overpricing