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10.3892/ijmm.2021.4876 http://scihub22266oqcxt.onion/10.3892/ijmm.2021.4876 33576441!7891831!33576441     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2021 ; 47 (4): ä Nephropedia Template TP {{tp|p=33576441|t=2021. Determining available strategies for prevention and therapy: Exploring COVID?19 from the perspective of ACE2 (Review) |pdf=|usr=}}{{33576441}} gab.com Text Determining available strategies for prevention and therapy: Exploring COVID 19 from the perspective of ACE2 (Review) JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33576441 #FOAvip Coronavirus disease 2019 (COVID?19) is an acute infectious pneumonia caused by a novel type of coronavirus infection. There are currently no clinically available specific drugs for the treatment of this virus. The process of host invasion is the key to viral infection, and it is a mechanism that needs to be considered when exploring antiviral drugs. At present, studies have confirmed that angiotensin?converting enzyme II (ACE2) is the main functional receptor through which severe acute respiratory syndrome coronavirus (SARS?CoV?2) invades host cells. Therefore, a number of studies have focused on this field. However, as ACE2 may play a dual role in mediating susceptibility and immunity to SARS?CoV?2 infection, the role of ACE2 in viral infection is controversial. Beginning with the physiological function of ACE2, the present review article summarizes the influence of the ACE2 content on the susceptibility to the virus and acute lung injury. Drug mechanisms were taken as the starting point, combined with the results of clinical trials, specifically elaborating upon and analyzing the efficacy of several ACE2?centered therapeutic drugs and their potential effects. In addition, the current status of ACE2 as a targeted therapy for COVID?19 is discussed in order to provide new insight into the clinical prevention and treatment of COVID?19. Twit Text FOAVip Determining available strategies for prevention and therapy: Exploring COVID 19 from the perspective of ACE2 (Review) ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33576441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33576441 #FOAvip English Wikipedia <ref>{{Cite pmid|33576441}}</ref> Determining available strategies for prevention and therapy: Exploring COVID?19 from the perspective of ACE2 (Review) #MMPMID33576441 Cai L; Guo X; Cao Y; Ying P; Hong L; Zhang Y; Yi G; Fu M Int J Mol Med 2021[Apr]; 47 (4): ä PMID33576441show ga Coronavirus disease 2019 (COVID?19) is an acute infectious pneumonia caused by a novel type of coronavirus infection. There are currently no clinically available specific drugs for the treatment of this virus. The process of host invasion is the key to viral infection, and it is a mechanism that needs to be considered when exploring antiviral drugs. At present, studies have confirmed that angiotensin?converting enzyme II (ACE2) is the main functional receptor through which severe acute respiratory syndrome coronavirus (SARS?CoV?2) invades host cells. Therefore, a number of studies have focused on this field. However, as ACE2 may play a dual role in mediating susceptibility and immunity to SARS?CoV?2 infection, the role of ACE2 in viral infection is controversial. Beginning with the physiological function of ACE2, the present review article summarizes the influence of the ACE2 content on the susceptibility to the virus and acute lung injury. Drug mechanisms were taken as the starting point, combined with the results of clinical trials, specifically elaborating upon and analyzing the efficacy of several ACE2?centered therapeutic drugs and their potential effects. In addition, the current status of ACE2 as a targeted therapy for COVID?19 is discussed in order to provide new insight into the clinical prevention and treatment of COVID?19. |Angiotensin-Converting Enzyme 2/antagonists & inhibitors/pharmacology/*physiology[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19/*prevention & control/*therapy/virology[MESH] |Cardiovascular Diseases/etiology[MESH] |Chloroquine/analogs & derivatives/pharmacology[MESH] |Host-Pathogen Interactions/drug effects/*physiology[MESH] |Humans[MESH] |Indoles/pharmacology[MESH] |Molecular Targeted Therapy[MESH] |SARS-CoV-2/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]Determining available strategies for prevention and therapy: Exploring(epmc).pdf DeepDyve Pubget Overpricing