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10.1093/oxfimm/iqaa007 http://scihub22266oqcxt.onion/10.1093/oxfimm/iqaa007 33575657!7798577!33575657     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33575657&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Oxf+Open+Immunol 2021 ; 2 (1): iqaa007 Nephropedia Template TP {{tp|p=33575657|t=2021. T cell phenotypes in COVID-19 - a living review |pdf=|usr=}}{{33575657}} gab.com Text T cell phenotypes in COVID-19 - a living review JO: Oxf Open Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33575657 #FOAvip COVID-19 is characterized by profound lymphopenia in the peripheral blood, and the remaining T cells display altered phenotypes, characterized by a spectrum of activation and exhaustion. However, antigen-specific T cell responses are emerging as a crucial mechanism for both clearance of the virus and as the most likely route to long-lasting immune memory that would protect against re-infection. Therefore, T cell responses are also of considerable interest in vaccine development. Furthermore, persistent alterations in T cell subset composition and function post-infection have important implications for patients' long-term immune function. In this review, we examine T cell phenotypes, including those of innate T cells, in both peripheral blood and lungs, and consider how key markers of activation and exhaustion correlate with, and may be able to predict, disease severity. We focus on SARS-CoV-2-specific T cells to elucidate markers that may indicate formation of antigen-specific T cell memory. We also examine peripheral T cell phenotypes in recovery and the likelihood of long-lasting immune disruption. Finally, we discuss T cell phenotypes in the lung as important drivers of both virus clearance and tissue damage. As our knowledge of the adaptive immune response to COVID-19 rapidly evolves, it has become clear that while some areas of the T cell response have been investigated in some detail, others, such as the T cell response in children remain largely unexplored. Therefore, this review will also highlight areas where T cell phenotypes require urgent characterisation. Twit Text FOAVip T cell phenotypes in COVID-19 - a living review ????Oxf Open Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33575657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33575657 #FOAvip English Wikipedia <ref>{{Cite pmid|33575657}}</ref> T cell phenotypes in COVID-19 - a living review #MMPMID33575657 Hanna SJ; Codd AS; Gea-Mallorqui E; Scourfield DO; Richter FC; Ladell K; Borsa M; Compeer EB; Moon OR; Galloway SAE; Dimonte S; Capitani L; Shepherd FR; Wilson JD; Uhl LFK; Gallimore AM; Milicic A Oxf Open Immunol 2021[]; 2 (1): iqaa007 PMID33575657show ga COVID-19 is characterized by profound lymphopenia in the peripheral blood, and the remaining T cells display altered phenotypes, characterized by a spectrum of activation and exhaustion. However, antigen-specific T cell responses are emerging as a crucial mechanism for both clearance of the virus and as the most likely route to long-lasting immune memory that would protect against re-infection. Therefore, T cell responses are also of considerable interest in vaccine development. Furthermore, persistent alterations in T cell subset composition and function post-infection have important implications for patients' long-term immune function. In this review, we examine T cell phenotypes, including those of innate T cells, in both peripheral blood and lungs, and consider how key markers of activation and exhaustion correlate with, and may be able to predict, disease severity. We focus on SARS-CoV-2-specific T cells to elucidate markers that may indicate formation of antigen-specific T cell memory. We also examine peripheral T cell phenotypes in recovery and the likelihood of long-lasting immune disruption. Finally, we discuss T cell phenotypes in the lung as important drivers of both virus clearance and tissue damage. As our knowledge of the adaptive immune response to COVID-19 rapidly evolves, it has become clear that while some areas of the T cell response have been investigated in some detail, others, such as the T cell response in children remain largely unexplored. Therefore, this review will also highlight areas where T cell phenotypes require urgent characterisation. äT cell phenotypes in COVID-19 - a living review (epmc).pdf DeepDyve Pubget Overpricing