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10.1183/13993003.04015-2020

http://scihub22266oqcxt.onion/10.1183/13993003.04015-2020
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suck abstract from ncbi

pmid33574080      Eur+Respir+J 2021 ; 58 (3): ?
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  • Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life #MMPMID33574080
  • Anastasio F; Barbuto S; Scarnecchia E; Cosma P; Fugagnoli A; Rossi G; Parravicini M; Parravicini P
  • Eur Respir J 2021[Sep]; 58 (3): ? PMID33574080show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread worldwide, having a dramatic impact on healthcare systems. The aim of this study is to evaluate mid-term clinical impact of COVID-19 on respiratory function. METHODS: 379 patients were evaluated 4 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis. Patients were divided in two groups based on the presence of pneumonia during COVID-19. Clinical conditions, quality of life, symptomatology, 6-min walk test, pulmonary function test with spirometry and diffusing capacity of the lung for carbon monoxide were analysed. Data were compared to clinical evolution during COVID-19 (development of acute respiratory distress syndrome, need of invasive mechanical ventilation, partial oxygen saturation (S (pO(2)) )/inspiratory oxygen fraction (F (IO(2)) ) ratio and pneumonia severity index (PSI)). RESULTS: After a median 135 days, 260 (68.6%) out of 379 patients referred at least one symptom. Patients who developed pneumonia during COVID-19 showed lower S (pO(2)) at rest (p<0.001), S (pO(2)) during 6-min walk test (p<0.001), total lung capacity (p<0.001), airway occlusion pressure after 0.1 s (P (0.1)) (p=0.02), P (0.1)/maximal inspiratory pressure ratio (p=0.005) and higher Borg category-ratio scale (p=0.006) and modified Medical Research Council breathlessness scale (p=0.003), compared to patients without pneumonia. S (pO(2)) /F (IO(2)) ratio and PSI during SARS-CoV-2 pneumonia were directly associated with mid-term alteration of S (pO(2)) at rest (p<0.001) and during 6-min walk test (p<0.001), residual volume (p<0.001), total lung capacity (p<0.001 and p=0.003, respectively) and forced vital capacity (p=0.004 and p=0.03, respectively). CONCLUSION: Lung damage during COVID-19 correlates to the reduction of pulmonary function 4 months after acute infection.
  • |*COVID-19[MESH]
  • |*Quality of Life[MESH]
  • |Humans[MESH]
  • |Lung[MESH]
  • |Respiratory Function Tests[MESH]


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