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10.1183/13993003.03677-2020

http://scihub22266oqcxt.onion/10.1183/13993003.03677-2020
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33574077!7877322!33574077
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suck abstract from ncbi


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pmid33574077      Eur+Respir+J 2021 ; 58 (1): ä
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  • Diffusion capacity abnormalities for carbon monoxide in patients with COVID-19 at 3-month follow-up #MMPMID33574077
  • Qin W; Chen S; Zhang Y; Dong F; Zhang Z; Hu B; Zhu Z; Li F; Wang X; Wang Y; Zhen K; Wang J; Wan Y; Li H; Elalamy I; Li C; Zhai Z; Wang C
  • Eur Respir J 2021[Jul]; 58 (1): ä PMID33574077show ga
  • OBJECTIVE: To evaluate pulmonary function and clinical symptoms in coronavirus disease 2019 (COVID-19) survivors within 3 months after hospital discharge, and to identify risk factors associated with impaired lung function. METHODS AND MATERIAL: COVID-19 patients were prospectively followed-up with pulmonary function tests and clinical characteristics for 3 months following discharge from a hospital in Wuhan, China between January and February 2020. RESULTS: 647 patients were included. 87 (13%) patients presented with weakness, 63 (10%) with palpitations and 56 (9%) with dyspnoea. The prevalence of each of the three symptoms were markedly higher in severe patients than nonsevere patients (19% versus 10% for weakness, p=0.003; 14% versus 7% for palpitations, p=0.007; 12% versus 7% for dyspnoea, p=0.014). Results of multivariable regression showed increased odds of ongoing symptoms among severe patients (OR 1.7, 95% CI 1.1-2.6; p=0.026) or patients with longer hospital stays (OR 1.03, 95% CI 1.00-1.05; p=0.041). Pulmonary function test results were available for 81 patients, including 41 nonsevere and 40 severe patients. In this subgroup, 44 (54%) patients manifested abnormal diffusing capacity of the lung for carbon monoxide (D (LCO)) (68% severe versus 42% nonsevere patients, p=0.019). Chest computed tomography (CT) total severity score >10.5 (OR 10.4, 95% CI 2.5-44.1; p=0.001) on admission and acute respiratory distress syndrome (ARDS) (OR 4.6, 95% CI 1.4-15.5; p=0.014) were significantly associated with impaired D (LCO). Pulmonary interstitial damage may be associated with abnormal D (LCO). CONCLUSION: Pulmonary function, particularly D (LCO), declined in COVID-19 survivors. This decrease was associated with total severity score of chest CT >10.5 and ARDS occurrence. Pulmonary interstitial damage might contribute to the imparied D (LCO).
  • |*COVID-19[MESH]
  • |*Carbon Monoxide[MESH]
  • |China[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging[MESH]


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