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10.1183/13993003.04283-2020

http://scihub22266oqcxt.onion/10.1183/13993003.04283-2020
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33574074!7877323!33574074
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suck abstract from ncbi


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pmid33574074      Eur+Respir+J 2021 ; 58 (3): ä
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  • Point-of-care lung ultrasound assessment for risk stratification and therapy guiding in COVID-19 patients: a prospective noninterventional study #MMPMID33574074
  • Rubio-Gracia J; Gimenez-Lopez I; Garces-Horna V; Lopez-Delgado D; Sierra-Monzon JL; Martinez-Lostao L; Josa-Laorden C; Ruiz-Laiglesia F; Perez-Calvo JI; Crespo-Aznarez S; Garcia-Lafuente J; Pena Fresneda N; Amores Arriaga B; Gracia-Tello B; Sanchez-Marteles M
  • Eur Respir J 2021[Sep]; 58 (3): ä PMID33574074show ga
  • BACKGROUND: Lung ultrasound is feasible for assessing lung injury caused by coronavirus disease 2019 (COVID-19). However, the prognostic meaning and time-line changes of lung injury assessed by lung ultrasound in COVID-19 hospitalised patients are unknown. METHODS: Prospective cohort study designed to analyse prognostic value of lung ultrasound in COVID-19 patients by using a quantitative scale (lung ultrasound Zaragoza (LUZ)-score) during the first 72 h after admission. The primary end-point was in-hospital death and/or admission to the intensive care unit. Total length of hospital stay, increase of oxygen flow and escalation of medical treatment during the first 72 h were secondary end-points. RESULTS: 130 patients were included in the final analysis; mean+/-sd age was 56.7+/-13.5 years. Median (interquartile range) time from the beginning of symptoms to admission was 6 (4-9) days. Lung injury assessed by LUZ-score did not differ during the first 72 h (21 (16-26) points at admission versus 20 (16-27) points at 72 h; p=0.183). In univariable logistic regression analysis, estimated arterial oxygen tension/inspiratory oxygen fraction ratio (PAFI) (hazard ratio 0.99, 95% CI 0.98-0.99; p=0.027) and LUZ-score >22 points (5.45, 1.42-20.90; p=0.013) were predictors for the primary end-point. CONCLUSIONS: LUZ-score is an easy, simple and fast point-of-care ultrasound tool to identify patients with severe lung injury due to COVID-19, upon admission. Baseline score is predictive of severity along the whole period of hospitalisation. The score facilitates early implementation or intensification of treatment for COVID-19 infection. LUZ-score may be combined with clinical variables (as estimated by PAFI) to further refine risk stratification.
  • |*COVID-19[MESH]
  • |*Point-of-Care Systems[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]
  • |Risk Assessment[MESH]


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