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10.26508/lsa.202000886 http://scihub22266oqcxt.onion/10.26508/lsa.202000886 33574037!7893819!33574037     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci+Alliance 2021 ; 4 (4): ä Nephropedia Template TP {{tp|p=33574037|t=2021. SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters |pdf=|usr=}}{{33574037}} gab.com Text SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters JO: Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=33574037 #FOAvip A critical question in understanding the immunity to SARS-COV-2 is whether recovered patients are protected against re-challenge and transmission upon second exposure. We developed a Syrian hamster model in which intranasal inoculation of just 100 TCID(50) virus caused viral pneumonia. Aged hamsters developed more severe disease and even succumbed to SARS-CoV-2 infection, representing the first lethal model using genetically unmodified laboratory animals. After initial viral clearance, the hamsters were re-challenged with 10(5) TCID(50) SARS-CoV-2 and displayed more than 4 log reduction in median viral loads in both nasal washes and lungs in comparison to primary infections. Most importantly, re-challenged hamsters were unable to transmit virus to naive hamsters, and this was accompanied by the presence of neutralizing antibodies. Altogether, these results show that SARS-CoV-2 infection induces protective immunity that not only prevents re-exposure but also limits transmission in hamsters. These findings may help guide public health policies and vaccine development and aid evaluation of effective vaccines against SARS-CoV-2. Twit Text FOAVip SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters ????Life Sci Alliance http://www.kidney.de/pget.php?&tw=1&pmid=33574037 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33574037 #FOAvip English Wikipedia <ref>{{Cite pmid|33574037}}</ref> SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters #MMPMID33574037 Selvaraj P; Lien CZ; Liu S; Stauft CB; Nunez IA; Hernandez M; Nimako E; Ortega MA; Starost MF; Dennis JU; Wang TT Life Sci Alliance 2021[Apr]; 4 (4): ä PMID33574037show ga A critical question in understanding the immunity to SARS-COV-2 is whether recovered patients are protected against re-challenge and transmission upon second exposure. We developed a Syrian hamster model in which intranasal inoculation of just 100 TCID(50) virus caused viral pneumonia. Aged hamsters developed more severe disease and even succumbed to SARS-CoV-2 infection, representing the first lethal model using genetically unmodified laboratory animals. After initial viral clearance, the hamsters were re-challenged with 10(5) TCID(50) SARS-CoV-2 and displayed more than 4 log reduction in median viral loads in both nasal washes and lungs in comparison to primary infections. Most importantly, re-challenged hamsters were unable to transmit virus to naive hamsters, and this was accompanied by the presence of neutralizing antibodies. Altogether, these results show that SARS-CoV-2 infection induces protective immunity that not only prevents re-exposure but also limits transmission in hamsters. These findings may help guide public health policies and vaccine development and aid evaluation of effective vaccines against SARS-CoV-2. |*Immunity[MESH] |Age Factors[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/*immunology/*transmission/virology[MESH] |Chlorocebus aethiops[MESH] |Cricetinae[MESH] |Disease Models, Animal[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Male[MESH] |RNA, Viral/genetics[MESH] |Reinfection/*immunology/*transmission/virology[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Transfection[MESH] |Vero Cells[MESH]SARS-CoV-2 infection induces protective immunity and limits transmissi(epmc).pdf DeepDyve Pubget Overpricing