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10.1186/s12959-021-00263-0 http://scihub22266oqcxt.onion/10.1186/s12959-021-00263-0 33573670!7877314!33573670     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33573670&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Thromb+J 2021 ; 19 (1): 10 Nephropedia Template TP {{tp|p=33573670|t=2021. Pathological findings in rotation thromboelastometry associated with thromboembolic events in COVID-19 patients |pdf=|usr=}}{{33573670}} gab.com Text Pathological findings in rotation thromboelastometry associated with thromboembolic events in COVID-19 patients JO: Thromb J http://www.kidney.de/pget.php?&tw=1&pmid=33573670 #FOAvip BACKGROUND: Severe thromboembolic events are one of the major complications associated with COVID-19 infection, especially among critically ill patients. We analysed ROTEM measurements in COVID-19 patients with a severe disease course and in patients with severe sepsis. METHODS: In this study, data obtained by extended analysis of haemostasis with standard laboratory tests and thromboelastometry of 20 patients with severe course of COVID-19 were retrospectively analysed and compared with similar data from 20 patients with severe sepsis but no COVID-19. RESULTS: The thromboelastometry values obtained from 20 sepsis patients contained a maximum clot firmness above the normal range but among COVID-19 patients, hypercoagulability was much more pronounced, with significantly higher maximum clot firmness (FIBTEM: 38.4 +/- 10.1 mm vs. 29.6 +/- 10.8 mm; P = 0.012; EXTEM: 70.4 +/- 10.4 mm vs. 60.6 +/- 14.8 mm; P = 0.022). Additionally, fibrinogen levels were significantly higher among COVID-19 patients (757 +/- 135 mg/dl vs. 498 +/- 132 mg/dl, P < 0.0001). Furthermore, thromboelastometry showed fibrinolysis shutdown among COVID-19 patients with significantly lower maximum of lysis than among sepsis patients (EXTEM: 0.6 +/- 1.2 % vs. 3.3 +/- 3.7 %; P = 0.013). Seven of 20 COVID-19 patients experienced thromboembolic events, whereas no patient in the sepsis group experienced such events. CONCLUSIONS: ROTEM analysis showed significantly different pathological findings characterized by hypercoagulability and fibrinolysis shutdown among COVID-19 patients with a severe disease course compared to patients with severe sepsis. These abnormalities seem to be associated with thromboembolic events. Twit Text FOAVip Pathological findings in rotation thromboelastometry associated with thromboembolic events in COVID-19 patients ????Thromb J http://www.kidney.de/pget.php?&tw=1&pmid=33573670 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33573670 #FOAvip English Wikipedia <ref>{{Cite pmid|33573670}}</ref> Pathological findings in rotation thromboelastometry associated with thromboembolic events in COVID-19 patients #MMPMID33573670 Boss K; Kribben A; Tyczynski B Thromb J 2021[Feb]; 19 (1): 10 PMID33573670show ga BACKGROUND: Severe thromboembolic events are one of the major complications associated with COVID-19 infection, especially among critically ill patients. We analysed ROTEM measurements in COVID-19 patients with a severe disease course and in patients with severe sepsis. METHODS: In this study, data obtained by extended analysis of haemostasis with standard laboratory tests and thromboelastometry of 20 patients with severe course of COVID-19 were retrospectively analysed and compared with similar data from 20 patients with severe sepsis but no COVID-19. RESULTS: The thromboelastometry values obtained from 20 sepsis patients contained a maximum clot firmness above the normal range but among COVID-19 patients, hypercoagulability was much more pronounced, with significantly higher maximum clot firmness (FIBTEM: 38.4 +/- 10.1 mm vs. 29.6 +/- 10.8 mm; P = 0.012; EXTEM: 70.4 +/- 10.4 mm vs. 60.6 +/- 14.8 mm; P = 0.022). Additionally, fibrinogen levels were significantly higher among COVID-19 patients (757 +/- 135 mg/dl vs. 498 +/- 132 mg/dl, P < 0.0001). Furthermore, thromboelastometry showed fibrinolysis shutdown among COVID-19 patients with significantly lower maximum of lysis than among sepsis patients (EXTEM: 0.6 +/- 1.2 % vs. 3.3 +/- 3.7 %; P = 0.013). Seven of 20 COVID-19 patients experienced thromboembolic events, whereas no patient in the sepsis group experienced such events. CONCLUSIONS: ROTEM analysis showed significantly different pathological findings characterized by hypercoagulability and fibrinolysis shutdown among COVID-19 patients with a severe disease course compared to patients with severe sepsis. These abnormalities seem to be associated with thromboembolic events. ?Pathological findings in rotation thromboelastometry associated with (epmc).pdf DeepDyve Pubget Overpricing