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10.3390/molecules26030711

http://scihub22266oqcxt.onion/10.3390/molecules26030711
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33573088!7866518!33573088
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suck abstract from ncbi


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pmid33573088      Molecules 2021 ; 26 (3): ä
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  • In Silico Study of Polyunsaturated Fatty Acids as Potential SARS-CoV-2 Spike Protein Closed Conformation Stabilizers: Epidemiological and Computational Approaches #MMPMID33573088
  • Vivar-Sierra A; Araiza-Macias MJ; Hernandez-Contreras JP; Vergara-Castaneda A; Ramirez-Velez G; Pinto-Almazan R; Salazar JR; Loza-Mejia MA
  • Molecules 2021[Jan]; 26 (3): ä PMID33573088show ga
  • SARS-CoV-2 infects host cells by interacting its spike protein with surface angiotensin-converting enzyme 2 (ACE2) receptors, expressed in lung and other cell types. Although several risk factors could explain why some countries have lower incidence and fatality rates than others, environmental factors such as diet should be considered. It has been described that countries with high polyunsaturated fatty acid (PUFA) intake have a lower number of COVID-19 victims and a higher rate of recovery from the disease. Moreover, it was found that linoleic acid, an omega-6 PUFA, could stabilize the spike protein in a closed conformation, blocking its interaction with ACE2. These facts prompted us to perform in silico simulations to determine if other PUFA could also stabilize the closed conformation of spike protein and potentially lead to a reduction in SARS-CoV-2 infection. We found that: (a) countries whose source of omega-3 is from marine origin have lower fatality rates; and (b) like linoleic acid, omega-3 PUFA could also bind to the closed conformation of spike protein and therefore, could help reduce COVID-19 complications by reducing viral entrance to cells, in addition to their known anti-inflammatory effects.
  • |COVID-19/*epidemiology[MESH]
  • |Computer Simulation[MESH]
  • |Eating[MESH]
  • |Fatty Acids, Omega-3/pharmacology[MESH]
  • |Fatty Acids, Unsaturated/*chemistry/*metabolism/pharmacology[MESH]
  • |Humans[MESH]
  • |Molecular Docking Simulation[MESH]
  • |Molecular Dynamics Simulation[MESH]
  • |Seafood[MESH]
  • |Spike Glycoprotein, Coronavirus/*chemistry/*metabolism[MESH]


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