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10.3390/v13020217 http://scihub22266oqcxt.onion/10.3390/v13020217 33572589!7911487!33572589     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (2): ä Nephropedia Template TP {{tp|p=33572589|t=2021. More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation |pdf=|usr=}}{{33572589}} gab.com Text More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33572589 #FOAvip Serological assays detecting neutralising antibodies are important for determining the immune responses following infection or vaccination and are also often considered a correlate of protection. The target of neutralising antibodies is usually located in the Envelope protein on the viral surface, which mediates cell entry. As such, presentation of the Envelope protein on a lentiviral particle represents a convenient alternative to handling of a potentially high containment virus or for those viruses with no established cell culture system. The flexibility, relative safety and, in most cases, ease of production of lentiviral pseudotypes, have led to their use in serological assays for many applications such as the evaluation of candidate vaccines, screening and characterization of anti-viral therapeutics, and sero-surveillance. Above all, the speed of production of the lentiviral pseudotypes, once the envelope sequence is published, makes them important tools in the response to viral outbreaks, as shown during the COVID-19 pandemic in 2020. In this review, we provide an overview of the landscape of the serological applications of pseudotyped lentiviral vectors, with a brief discussion on their production and batch quality analysis. Finally, we evaluate their role as surrogates for the real virus and possible alternatives. Twit Text FOAVip More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33572589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33572589 #FOAvip English Wikipedia <ref>{{Cite pmid|33572589}}</ref> More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation #MMPMID33572589 Toon K; Bentley EM; Mattiuzzo G Viruses 2021[Jan]; 13 (2): ä PMID33572589show ga Serological assays detecting neutralising antibodies are important for determining the immune responses following infection or vaccination and are also often considered a correlate of protection. The target of neutralising antibodies is usually located in the Envelope protein on the viral surface, which mediates cell entry. As such, presentation of the Envelope protein on a lentiviral particle represents a convenient alternative to handling of a potentially high containment virus or for those viruses with no established cell culture system. The flexibility, relative safety and, in most cases, ease of production of lentiviral pseudotypes, have led to their use in serological assays for many applications such as the evaluation of candidate vaccines, screening and characterization of anti-viral therapeutics, and sero-surveillance. Above all, the speed of production of the lentiviral pseudotypes, once the envelope sequence is published, makes them important tools in the response to viral outbreaks, as shown during the COVID-19 pandemic in 2020. In this review, we provide an overview of the landscape of the serological applications of pseudotyped lentiviral vectors, with a brief discussion on their production and batch quality analysis. Finally, we evaluate their role as surrogates for the real virus and possible alternatives. |Animals[MESH] |Antiviral Agents[MESH] |COVID-19 Serological Testing/*methods[MESH] |COVID-19 Vaccines/administration & dosage[MESH] |COVID-19/blood/*diagnosis/*therapy[MESH] |Genetic Therapy/*methods[MESH] |Genetic Vectors/*genetics[MESH] |Humans[MESH] |Lentivirus/genetics[MESH]More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for(epmc).pdf DeepDyve Pubget Overpricing