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10.3390/nu13020562 http://scihub22266oqcxt.onion/10.3390/nu13020562 33572045!7914437!33572045     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutrients 2021 ; 13 (2): ä Nephropedia Template TP {{tp|p=33572045|t=2021. Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection |pdf=|usr=}}{{33572045}} gab.com Text Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=33572045 #FOAvip BACKGROUND: Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. METHODS: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. FINDINGS: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 microg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. INTERPRETATION: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency. Twit Text FOAVip Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=33572045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33572045 #FOAvip English Wikipedia <ref>{{Cite pmid|33572045}}</ref> Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection #MMPMID33572045 Vogel-Gonzalez M; Tallo-Parra M; Herrera-Fernandez V; Perez-Vilaro G; Chillon M; Nogues X; Gomez-Zorrilla S; Lopez-Montesinos I; Arnau-Barres I; Sorli-Redo ML; Horcajada JP; Garcia-Giralt N; Pascual J; Diez J; Vicente R; Guerri-Fernandez R Nutrients 2021[Feb]; 13 (2): ä PMID33572045show ga BACKGROUND: Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. METHODS: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. FINDINGS: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 microg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. INTERPRETATION: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency. |*SARS-CoV-2[MESH] |Aged[MESH] |Animals[MESH] |COVID-19/*blood/*pathology[MESH] |Cell Survival[MESH] |Chlorocebus aethiops[MESH] |Cohort Studies[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Vero Cells[MESH]Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in(epmc).pdf DeepDyve Pubget Overpricing