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10.1016/j.bbamem.2021.183584

http://scihub22266oqcxt.onion/10.1016/j.bbamem.2021.183584
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33571481!ä!33571481

suck abstract from ncbi


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pmid33571481      Biochim+Biophys+Acta+Biomembr 2021 ; 1863 (6): 183584
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  • A certain proportion of docosahexaenoic acid tends to revert structural and dynamical effects of cholesterol on lipid membranes #MMPMID33571481
  • Pedroni VI; Sierra MB; Alarcon LM; Verde AR; Appignanesi GA; Morini MA
  • Biochim Biophys Acta Biomembr 2021[Jun]; 1863 (6): 183584 PMID33571481show ga
  • This work investigates how docosahexaenoic acid (DHA) modifies the effect of Cholesterol (Chol) on the structural and dynamical properties of dipalmitoylphosphatidylcholine (DPPC) membrane. We employ low-cost and non-invasive methods: zeta potential (ZP), conductivity, density, and ultrasound velocity, complemented by molecular dynamics simulations. Our studies reveal that 30% of DHA added to the DPPC-Chol system tends to revert Chol action on a model lipid bilayer. Results obtained in this work shed light on the effect of polyunsaturated fatty acids - particularly DHA - on lipid membranes, with potential preventive applications in many diseases, e.g. neuronal as, Alzheimer's disease, and viral, as Covid-19.
  • |Cholesterol/*metabolism[MESH]
  • |Docosahexaenoic Acids/*metabolism[MESH]
  • |Lipid Bilayers/*metabolism[MESH]
  • |Liposomes[MESH]
  • |Molecular Structure[MESH]
  • |Phosphatidylcholines/*metabolism[MESH]
  • |Temperature[MESH]


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