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10.1016/S2352-4642(21)00024-9 http://scihub22266oqcxt.onion/10.1016/S2352-4642(21)00024-9 33571450!9180428!33571450     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lancet+Child+Adolesc+Health 2021 ; 5 (4): 256-264 Nephropedia Template TP {{tp|p=33571450|t=2021. SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study |pdf=|usr=}}{{33571450}} gab.com Text SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study JO: Lancet Child Adolesc Health http://www.kidney.de/pget.php?&tw=1&pmid=33571450 #FOAvip BACKGROUND: The extent to which very young children contribute to the transmission of SARS-CoV-2 is unclear. We aimed to estimate the seroprevalence of antibodies against SARS-CoV-2 in daycare centres that remained open for key workers' children during a nationwide lockdown in France. METHODS: Children and staff who attended one of 22 daycare centres during a nationwide lockdown in France (between March 15 and May 9, 2020) were included in this cross-sectional, multicentre, seroprevalence study. Hospital staff not occupationally exposed to patients with COVID-19, or to children, were enrolled in a comparator group. The primary outcome was SARS-CoV-2 seroprevalence in children, daycare centre staff, and the comparator group. The presence of antibodies against SARS-CoV-2 in capillary whole blood was measured with a rapid chromatographic immunoassay. We computed raw prevalence as the percentage of individuals with a positive IgG or IgM test, and used Bayesian smoothing to account for imperfect sensitivity and specificity of the assay. This study is registered with ClinicalTrials.gov, NCT04413968. FINDINGS: Between June 4 and July 3, 2020, we enrolled 327 children (mean age 1.9 [SD 0.9] years; range 5 months to 4.4 years), 197 daycare centre staff (mean age 40 [12] years), and 164 adults in the comparator group (42 [12] years). Positive serological tests were observed for 14 children (raw seroprevalence 4.3%; 95% CI 2.6-7.1) and 14 daycare centre staff (7.7%; 4.2-11.6). After accounting for imperfect sensitivity and specificity of the assay, we estimated that 3.7% (95% credible interval [95% CrI] 1.3-6.8) of the children and 6.8% (3.2-11.5) of daycare centre staff had SARS-CoV-2 infection. The comparator group fared similarly to the daycare centre staff; nine participants had a positive serological test (raw seroprevalence 5.5%; 95% CI 2.9-10.1), leading to a seroprevalence of 5.0% (95% CrI 1.6-9.8) after accounting for assay characteristics. An exploratory analysis suggested that seropositive children were more likely than seronegative children to have been exposed to an adult household member with laboratory-confirmed COVID-19 (six [43%] of 14 vs 19 [6%] of 307; relative risk 7.1 [95% CI 2.2-22.4]). INTERPRETATION: According to serological test results, the proportion of young children in our sample with SARS-CoV-2 infection was low. Intrafamily transmission seemed more plausible than transmission within daycare centres. Further epidemiological studies are needed to confirm this exploratory hypothesis. FUNDING: Assistance Publique-Hopitaux de Paris; Mairie de Paris, Conseil Departemental de Seine Saint Denis. TRANSLATIONS: For the French translation of the abstract see Supplementary Materials section. Twit Text FOAVip SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study ????Lancet Child Adolesc Health http://www.kidney.de/pget.php?&tw=1&pmid=33571450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33571450 #FOAvip English Wikipedia <ref>{{Cite pmid|33571450}}</ref> SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study #MMPMID33571450 Lachassinne E; de Pontual L; Caseris M; Lorrot M; Guilluy C; Naud A; Dommergues MA; Pinquier D; Wannepain E; Hausherr E; Jung C; Gajdos V; Cohen R; Zahar JR; Brichler S; Basmaci R; Boelle PY; Bloch-Queyrat C; Aupiais C Lancet Child Adolesc Health 2021[Apr]; 5 (4): 256-264 PMID33571450show ga BACKGROUND: The extent to which very young children contribute to the transmission of SARS-CoV-2 is unclear. We aimed to estimate the seroprevalence of antibodies against SARS-CoV-2 in daycare centres that remained open for key workers' children during a nationwide lockdown in France. METHODS: Children and staff who attended one of 22 daycare centres during a nationwide lockdown in France (between March 15 and May 9, 2020) were included in this cross-sectional, multicentre, seroprevalence study. Hospital staff not occupationally exposed to patients with COVID-19, or to children, were enrolled in a comparator group. The primary outcome was SARS-CoV-2 seroprevalence in children, daycare centre staff, and the comparator group. The presence of antibodies against SARS-CoV-2 in capillary whole blood was measured with a rapid chromatographic immunoassay. We computed raw prevalence as the percentage of individuals with a positive IgG or IgM test, and used Bayesian smoothing to account for imperfect sensitivity and specificity of the assay. This study is registered with ClinicalTrials.gov, NCT04413968. FINDINGS: Between June 4 and July 3, 2020, we enrolled 327 children (mean age 1.9 [SD 0.9] years; range 5 months to 4.4 years), 197 daycare centre staff (mean age 40 [12] years), and 164 adults in the comparator group (42 [12] years). Positive serological tests were observed for 14 children (raw seroprevalence 4.3%; 95% CI 2.6-7.1) and 14 daycare centre staff (7.7%; 4.2-11.6). After accounting for imperfect sensitivity and specificity of the assay, we estimated that 3.7% (95% credible interval [95% CrI] 1.3-6.8) of the children and 6.8% (3.2-11.5) of daycare centre staff had SARS-CoV-2 infection. The comparator group fared similarly to the daycare centre staff; nine participants had a positive serological test (raw seroprevalence 5.5%; 95% CI 2.9-10.1), leading to a seroprevalence of 5.0% (95% CrI 1.6-9.8) after accounting for assay characteristics. An exploratory analysis suggested that seropositive children were more likely than seronegative children to have been exposed to an adult household member with laboratory-confirmed COVID-19 (six [43%] of 14 vs 19 [6%] of 307; relative risk 7.1 [95% CI 2.2-22.4]). INTERPRETATION: According to serological test results, the proportion of young children in our sample with SARS-CoV-2 infection was low. Intrafamily transmission seemed more plausible than transmission within daycare centres. Further epidemiological studies are needed to confirm this exploratory hypothesis. FUNDING: Assistance Publique-Hopitaux de Paris; Mairie de Paris, Conseil Departemental de Seine Saint Denis. TRANSLATIONS: For the French translation of the abstract see Supplementary Materials section. |*Child Day Care Centers[MESH] |Adult[MESH] |Antibodies, Viral/*blood[MESH] |COVID-19/*transmission[MESH] |Child, Preschool[MESH] |Cross-Sectional Studies[MESH] |France/epidemiology[MESH] |Humans[MESH] |Immunoassay[MESH] |Immunoglobulin G/blood[MESH] |Immunoglobulin M/blood[MESH] |Infant[MESH] |SARS-CoV-2/*immunology[MESH]SARS-CoV-2 transmission among children and staff in daycare centres du(epmc).pdf DeepDyve Pubget Overpricing