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10.1016/j.cell.2021.01.050 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.01.050 33571429!7994111!33571429     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (5): 1201-1213.e14 Nephropedia Template TP {{tp|p=33571429|t=2021. Maturation and persistence of the anti-SARS-CoV-2 memory B cell response |pdf=|usr=}}{{33571429}} gab.com Text Maturation and persistence of the anti-SARS-CoV-2 memory B cell response JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33571429 #FOAvip Memory B cells play a fundamental role in host defenses against viruses, but to date, their role has been relatively unsettled in the context of SARS-CoV-2. We report here a longitudinal single-cell and repertoire profiling of the B cell response up to 6 months in mild and severe COVID-19 patients. Distinct SARS-CoV-2 spike-specific activated B cell clones fueled an early antibody-secreting cell burst as well as a durable synchronous germinal center response. While highly mutated memory B cells, including pre-existing cross-reactive seasonal Betacoronavirus-specific clones, were recruited early in the response, neutralizing SARS-CoV-2 RBD-specific clones accumulated with time and largely contributed to the late, remarkably stable, memory B cell pool. Highlighting germinal center maturation, these cells displayed clear accumulation of somatic mutations in their variable region genes over time. Overall, these findings demonstrate that an antigen-driven activation persisted and matured up to 6 months after SARS-CoV-2 infection and may provide long-term protection. Twit Text FOAVip Maturation and persistence of the anti-SARS-CoV-2 memory B cell response ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33571429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33571429 #FOAvip English Wikipedia <ref>{{Cite pmid|33571429}}</ref> Maturation and persistence of the anti-SARS-CoV-2 memory B cell response #MMPMID33571429 Sokal A; Chappert P; Barba-Spaeth G; Roeser A; Fourati S; Azzaoui I; Vandenberghe A; Fernandez I; Meola A; Bouvier-Alias M; Crickx E; Beldi-Ferchiou A; Hue S; Languille L; Michel M; Baloul S; Noizat-Pirenne F; Luka M; Megret J; Menager M; Pawlotsky JM; Fillatreau S; Rey FA; Weill JC; Reynaud CA; Mahevas M Cell 2021[Mar]; 184 (5): 1201-1213.e14 PMID33571429show ga Memory B cells play a fundamental role in host defenses against viruses, but to date, their role has been relatively unsettled in the context of SARS-CoV-2. We report here a longitudinal single-cell and repertoire profiling of the B cell response up to 6 months in mild and severe COVID-19 patients. Distinct SARS-CoV-2 spike-specific activated B cell clones fueled an early antibody-secreting cell burst as well as a durable synchronous germinal center response. While highly mutated memory B cells, including pre-existing cross-reactive seasonal Betacoronavirus-specific clones, were recruited early in the response, neutralizing SARS-CoV-2 RBD-specific clones accumulated with time and largely contributed to the late, remarkably stable, memory B cell pool. Highlighting germinal center maturation, these cells displayed clear accumulation of somatic mutations in their variable region genes over time. Overall, these findings demonstrate that an antigen-driven activation persisted and matured up to 6 months after SARS-CoV-2 infection and may provide long-term protection. |*Immunologic Memory[MESH] |Adult[MESH] |B-Lymphocytes/*immunology[MESH] |COVID-19/*immunology/physiopathology[MESH] |Flow Cytometry[MESH] |Germinal Center/cytology[MESH] |Humans[MESH] |Lymphocyte Activation[MESH] |Middle Aged[MESH] |Severity of Illness Index[MESH] |Single-Cell Analysis[MESH]Maturation and persistence of the anti-SARS-CoV-2 memory B cell respon(epmc).pdf DeepDyve Pubget Overpricing