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10.12659/MSM.926751

http://scihub22266oqcxt.onion/10.12659/MSM.926751
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33571171!7885294!33571171
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suck abstract from ncbi


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pmid33571171      Med+Sci+Monit 2021 ; 27 (ä): e926751
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  • Risk Factors of Coronavirus Disease 2019-Related Mortality and Optimal Treatment Regimens: A Retrospective Study #MMPMID33571171
  • Wang Y; Yao S; Liu X; Cao Y; Wang Y; Xie M
  • Med Sci Monit 2021[Feb]; 27 (ä): e926751 PMID33571171show ga
  • BACKGROUND Coronavirus disease 2019 (COVID-19) is spreading rapidly worldwide, and scientists are trying to find a way to overcome the disease. We explored the risk factors that influence patient outcomes, including treatment regimens, which can provide a reference for further treatment. MATERIAL AND METHODS A retrospective cohort study analysis was performed using data from 97 patients with COVID-19 who visited Wuhan Union Hospital from February 2020 to March 2020. We collected data on demographics, comorbidities, clinical manifestations, laboratory tests, treatment methods, outcomes, and complications. Patients were divided into a recovered group and a deceased group. We compared the differences between the 2 groups and analyzed risk factors influencing the treatment effect. RESULTS Seventy-six patients recovered and 21 died. The average age and body mass index (BMI) of the deceased group were significantly higher than those of the recovered group (69.81+/-6.80 years vs 60.79+/-11.28 years, P<0.001 and 24.95+/-3.14 kg/m(2) vs 23.09+/-2.97 kg/m(2), P=0.014, respectively). The combination of antiviral drugs and supportive therapy appears to be associated with the lowest mortality (P<0.05). Multivariate Cox regression analysis revealed that age, BMI, H-CRP, shock, and acute respiratory distress syndrome (ARDS) were independent risk factors for patients with COVID-19 (P<0.05). CONCLUSIONS Elderly patients and those with a high BMI, as well as patients who experience shock and ARDS, may have a higher risk of death from COVID-19. The combination of antiviral drugs and supportive therapy appears to be associated with lower mortality, although further research is needed.
  • |*COVID-19 Drug Treatment[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19/complications/*mortality/virology[MESH]
  • |China/epidemiology[MESH]
  • |Drug Therapy, Combination/methods[MESH]
  • |Drugs, Chinese Herbal/therapeutic use[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Kaplan-Meier Estimate[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prognosis[MESH]
  • |Respiratory Distress Syndrome/etiology/*mortality/therapy[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/isolation & purification/pathogenicity[MESH]
  • |Shock/etiology/*mortality/therapy[MESH]
  • |Treatment Outcome[MESH]


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