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10.1172/JCI146927 http://scihub22266oqcxt.onion/10.1172/JCI146927 33571169!8011893!33571169     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (7): ä Nephropedia Template TP {{tp|p=33571169|t=2021. Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality |pdf=|usr=}}{{33571169}} gab.com Text Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33571169 #FOAvip SARS-CoV-2 (CoV2) antibody therapies, including COVID-19 convalescent plasma (CCP), monoclonal antibodies, and hyperimmune globulin, are among the leading treatments for individuals with early COVID-19 infection. The functionality of convalescent plasma varies greatly, but the association of antibody epitope specificities with plasma functionality remains uncharacterized. We assessed antibody functionality and reactivities to peptides across the CoV2 and the 4 endemic human coronavirus (HCoV) genomes in 126 CCP donations. We found strong correlation between plasma functionality and polyclonal antibody targeting of CoV2 spike protein peptides. Antibody reactivity to many HCoV spike peptides also displayed strong correlation with plasma functionality, including pan-coronavirus cross-reactive epitopes located in a conserved region of the fusion peptide. After accounting for antibody cross-reactivity, we identified an association between greater alphacoronavirus NL63 antibody responses and development of highly neutralizing antibodies against CoV2. We also found that plasma preferentially reactive to the CoV2 spike receptor binding domain (RBD), versus the betacoronavirus HKU1 RBD, had higher neutralizing titer. Finally, we developed a 2-peptide serosignature that identifies plasma donations with high anti-spike titer, but that suffer from low neutralizing activity. These results suggest that analysis of coronavirus antibody fine specificities may be useful for selecting desired therapeutics and understanding the complex immune responses elicited by CoV2 infection. Twit Text FOAVip Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=33571169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33571169 #FOAvip English Wikipedia <ref>{{Cite pmid|33571169}}</ref> Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality #MMPMID33571169 Morgenlander WR; Henson SN; Monaco DR; Chen A; Littlefield K; Bloch EM; Fujimura E; Ruczinski I; Crowley AR; Natarajan H; Butler SE; Weiner JA; Li MZ; Bonny TS; Benner SE; Balagopal A; Sullivan D; Shoham S; Quinn TC; Eshleman SH; Casadevall A; Redd AD; Laeyendecker O; Ackerman ME; Pekosz A; Elledge SJ; Robinson M; Tobian AA; Larman HB J Clin Invest 2021[Apr]; 131 (7): ä PMID33571169show ga SARS-CoV-2 (CoV2) antibody therapies, including COVID-19 convalescent plasma (CCP), monoclonal antibodies, and hyperimmune globulin, are among the leading treatments for individuals with early COVID-19 infection. The functionality of convalescent plasma varies greatly, but the association of antibody epitope specificities with plasma functionality remains uncharacterized. We assessed antibody functionality and reactivities to peptides across the CoV2 and the 4 endemic human coronavirus (HCoV) genomes in 126 CCP donations. We found strong correlation between plasma functionality and polyclonal antibody targeting of CoV2 spike protein peptides. Antibody reactivity to many HCoV spike peptides also displayed strong correlation with plasma functionality, including pan-coronavirus cross-reactive epitopes located in a conserved region of the fusion peptide. After accounting for antibody cross-reactivity, we identified an association between greater alphacoronavirus NL63 antibody responses and development of highly neutralizing antibodies against CoV2. We also found that plasma preferentially reactive to the CoV2 spike receptor binding domain (RBD), versus the betacoronavirus HKU1 RBD, had higher neutralizing titer. Finally, we developed a 2-peptide serosignature that identifies plasma donations with high anti-spike titer, but that suffer from low neutralizing activity. These results suggest that analysis of coronavirus antibody fine specificities may be useful for selecting desired therapeutics and understanding the complex immune responses elicited by CoV2 infection. |Antibodies, Neutralizing/blood[MESH] |Antibodies, Viral/*blood[MESH] |Antibody Specificity[MESH] |COVID-19 Serotherapy[MESH] |COVID-19/*immunology/*therapy/*virology[MESH] |Coronavirus/classification/genetics/*immunology[MESH] |Cross Reactions[MESH] |Endemic Diseases[MESH] |Genome, Viral[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Immunodominant Epitopes/chemistry/genetics/immunology[MESH] |Models, Molecular[MESH] |Pandemics[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Species Specificity[MESH]Antibody responses to endemic coronaviruses modulate COVID-19 convales(epmc).pdf DeepDyve Pubget Overpricing