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10.1111/obr.13221 http://scihub22266oqcxt.onion/10.1111/obr.13221 33569904!7995014!33569904     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Obes+Rev 2021 ; 22 (4): e13221 Nephropedia Template TP {{tp|p=33569904|t=2021. Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19 |pdf=|usr=}}{{33569904}} gab.com Text Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19 JO: Obes Rev http://www.kidney.de/pget.php?&tw=1&pmid=33569904 #FOAvip Obesity and obesogenic comorbidities have been associated with COVID-19 susceptibility and mortality. However, the mechanism of such correlations requires an in-depth understanding. Overnutrition/excess serum amino acid profile during obesity has been linked with inflammation and reprogramming of translational machinery through hyperactivation of amino acid sensor mammalian target of rapamycin (mTOR), which is exploited by SARS-CoV-2 for its replication. Conversely, we have shown that the activation of general control nonderepressible 2 (GCN2)-dependent amino acid starvation sensing pathway suppresses intestinal inflammation by inhibiting the production of reactive oxygen species (ROS) and interleukin-1 beta (IL-1beta). While activation of GCN2 has shown to mitigate susceptibility to dengue infection, GCN2 deficiency increases viremia and inflammation-associated pathologies. These findings reveal that the amino acid sensing pathway plays a significant role in controlling inflammation and viral infections. The current fact is that obesity/excess amino acids/mTOR activation aggravates COVID-19, and it might be possible that activation of amino acid starvation sensor GCN2 has an opposite effect. This article focuses on the amino acid sensing pathways through which host cells sense the availability of amino acids and reprogram the host translation machinery to mount an effective antiviral response. Besides, how SARS-CoV-2 hijack and exploit amino acid sensing pathway for its replication and pathogenesis is also discussed. Twit Text FOAVip Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19 ????Obes Rev http://www.kidney.de/pget.php?&tw=1&pmid=33569904 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33569904 #FOAvip English Wikipedia <ref>{{Cite pmid|33569904}}</ref> Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19 #MMPMID33569904 Philips AM; Khan N Obes Rev 2021[Apr]; 22 (4): e13221 PMID33569904show ga Obesity and obesogenic comorbidities have been associated with COVID-19 susceptibility and mortality. However, the mechanism of such correlations requires an in-depth understanding. Overnutrition/excess serum amino acid profile during obesity has been linked with inflammation and reprogramming of translational machinery through hyperactivation of amino acid sensor mammalian target of rapamycin (mTOR), which is exploited by SARS-CoV-2 for its replication. Conversely, we have shown that the activation of general control nonderepressible 2 (GCN2)-dependent amino acid starvation sensing pathway suppresses intestinal inflammation by inhibiting the production of reactive oxygen species (ROS) and interleukin-1 beta (IL-1beta). While activation of GCN2 has shown to mitigate susceptibility to dengue infection, GCN2 deficiency increases viremia and inflammation-associated pathologies. These findings reveal that the amino acid sensing pathway plays a significant role in controlling inflammation and viral infections. The current fact is that obesity/excess amino acids/mTOR activation aggravates COVID-19, and it might be possible that activation of amino acid starvation sensor GCN2 has an opposite effect. This article focuses on the amino acid sensing pathways through which host cells sense the availability of amino acids and reprogram the host translation machinery to mount an effective antiviral response. Besides, how SARS-CoV-2 hijack and exploit amino acid sensing pathway for its replication and pathogenesis is also discussed. |*SARS-CoV-2/physiology[MESH] |Amino Acids/*metabolism[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/*epidemiology/physiopathology[MESH] |Comorbidity[MESH] |Humans[MESH] |Inflammation[MESH] |N-Acetylhexosaminyltransferases/*physiology[MESH] |Obesity/*epidemiology/physiopathology[MESH] |Protein Biosynthesis/physiology[MESH] |TOR Serine-Threonine Kinases/physiology[MESH]Amino acid sensing pathway: A major check point in the pathogenesis of(epmc).pdf DeepDyve Pubget Overpricing