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10.1016/j.dscb.2020.100001 http://scihub22266oqcxt.onion/10.1016/j.dscb.2020.100001 33569547!7869856!33569547     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33569547&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Brain+Disord 2021 ; 1 (?): ? Nephropedia Template TP {{tp|p=33569547|t=2021. Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress |pdf=|usr=}}{{33569547}} gab.com Text Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress JO: Brain Disord http://www.kidney.de/pget.php?&tw=1&pmid=33569547 #FOAvip The brain endothelium is an integral element of the blood-brain barrier (BBB). Dysfunction of this formation due to increased generation of reactive oxygen species (ROS) progresses the establishment of neurological disorders including stroke and traumatic brain injury. Heat shock protein 90 inhibitors are anti-inflammatory agents, and their activities are mediated, at least in part, by P53. This is a tumor suppressor protein which regulates the opposing activities of Rac1 and RhoA in the cellular cytoskeleton. In the present study we investigated the role of Hsp90 inhibitors in the H(2)O(2)-induced brain endothelium breakdown, by employing human cerebral microvascular endothelial cells (hCMEC/D3). Our findings suggest that H(2)O(2) downregulates P53 by enhancing the P53 suppressor mouse double minute 2 homolog (MDM2), as well as by increasing the apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref1). The H(2)O(2) - triggered violation of the brain endothelium barrier was reflected in measurements of transendothelial resistance, and the increased expression of the key cytoskeletal modulators cofilin and myosin light chain 2 (MLC2). Treatment of the hCMEC/D3 cells with Hsp90 inhibitors counteracted those events, and reduced the generation of the hydrogen peroxide - induced reactive oxygen species. Hence, our study suggests that Hsp90 inhibition supports the BBB integrity, and may represent a promising therapeutic approach for disorders associated with brain endothelium breakdown; including COVID-19. Twit Text FOAVip Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress ????Brain Disord http://www.kidney.de/pget.php?&tw=1&pmid=33569547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33569547 #FOAvip English Wikipedia <ref>{{Cite pmid|33569547}}</ref> Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress #MMPMID33569547 Uddin MA; Akhter MS; Kubra KT; Whitaker KE; Shipley SL; Smith LM; Barabutis N Brain Disord 2021[Mar]; 1 (?): ? PMID33569547show ga The brain endothelium is an integral element of the blood-brain barrier (BBB). Dysfunction of this formation due to increased generation of reactive oxygen species (ROS) progresses the establishment of neurological disorders including stroke and traumatic brain injury. Heat shock protein 90 inhibitors are anti-inflammatory agents, and their activities are mediated, at least in part, by P53. This is a tumor suppressor protein which regulates the opposing activities of Rac1 and RhoA in the cellular cytoskeleton. In the present study we investigated the role of Hsp90 inhibitors in the H(2)O(2)-induced brain endothelium breakdown, by employing human cerebral microvascular endothelial cells (hCMEC/D3). Our findings suggest that H(2)O(2) downregulates P53 by enhancing the P53 suppressor mouse double minute 2 homolog (MDM2), as well as by increasing the apyrimidinic endonuclease 1/redox factor 1 (APE1/Ref1). The H(2)O(2) - triggered violation of the brain endothelium barrier was reflected in measurements of transendothelial resistance, and the increased expression of the key cytoskeletal modulators cofilin and myosin light chain 2 (MLC2). Treatment of the hCMEC/D3 cells with Hsp90 inhibitors counteracted those events, and reduced the generation of the hydrogen peroxide - induced reactive oxygen species. Hence, our study suggests that Hsp90 inhibition supports the BBB integrity, and may represent a promising therapeutic approach for disorders associated with brain endothelium breakdown; including COVID-19. ?Hsp90 inhibition protects the brain microvascular endothelium against (epmc).pdf DeepDyve Pubget Overpricing