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10.3389/fimmu.2020.631743 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.631743 33569065!7868395!33569065     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 631743 Nephropedia Template TP {{tp|p=33569065|t=2020. Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases |pdf=|usr=}}{{33569065}} gab.com Text Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33569065 #FOAvip The concept of trained immunity has recently emerged as a mechanism contributing to several immune mediated inflammatory conditions. Trained immunity is defined by the immunological memory developed in innate immune cells after a primary non-specific stimulus that, in turn, promotes a heightened inflammatory response upon a secondary challenge. The most characteristic changes associated to this process involve the rewiring of cell metabolism and epigenetic reprogramming. Under physiological conditions, the role of trained immune cells ensures a prompt response. This action is limited by effective resolution of inflammation and tissue repair in order to restore homeostasis. However, unrestrained activation of innate immune cells contributes to the development of chronic inflammation and tissue destruction through the secretion of inflammatory cytokines, proteases and growth factors. Therefore, interventions aimed at reversing the changes induced by trained immunity provide potential therapeutic approaches to treat inflammatory and autoimmune diseases like rheumatoid arthritis (RA). We review cellular approaches that target metabolism and the epigenetic reprogramming of dendritic cells, macrophages, natural killer cells, and other trained cells in the context of autoimmune inflammatory diseases. Twit Text FOAVip Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33569065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33569065 #FOAvip English Wikipedia <ref>{{Cite pmid|33569065}}</ref> Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmune Diseases #MMPMID33569065 Municio C; Criado G Front Immunol 2020[]; 11 (ä): 631743 PMID33569065show ga The concept of trained immunity has recently emerged as a mechanism contributing to several immune mediated inflammatory conditions. Trained immunity is defined by the immunological memory developed in innate immune cells after a primary non-specific stimulus that, in turn, promotes a heightened inflammatory response upon a secondary challenge. The most characteristic changes associated to this process involve the rewiring of cell metabolism and epigenetic reprogramming. Under physiological conditions, the role of trained immune cells ensures a prompt response. This action is limited by effective resolution of inflammation and tissue repair in order to restore homeostasis. However, unrestrained activation of innate immune cells contributes to the development of chronic inflammation and tissue destruction through the secretion of inflammatory cytokines, proteases and growth factors. Therefore, interventions aimed at reversing the changes induced by trained immunity provide potential therapeutic approaches to treat inflammatory and autoimmune diseases like rheumatoid arthritis (RA). We review cellular approaches that target metabolism and the epigenetic reprogramming of dendritic cells, macrophages, natural killer cells, and other trained cells in the context of autoimmune inflammatory diseases. |Animals[MESH] |Anti-Inflammatory Agents/*therapeutic use[MESH] |Autoimmune Diseases/*drug therapy/genetics/immunology/metabolism[MESH] |Autoimmunity/*drug effects[MESH] |Biological Products/*therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/immunology[MESH] |Energy Metabolism/drug effects[MESH] |Epigenesis, Genetic/drug effects[MESH] |Humans[MESH] |Immune System/*drug effects/immunology/metabolism[MESH] |Immunity, Innate/drug effects[MESH] |Immunologic Memory/drug effects[MESH] |Inflammation/*drug therapy/genetics/immunology/metabolism[MESH]Therapies Targeting Trained Immune Cells in Inflammatory and Autoimmun(epmc).pdf DeepDyve Pubget Overpricing