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10.1186/s12879-021-05829-x

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suck abstract from ncbi


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pmid33568104      BMC+Infect+Dis 2021 ; 21 (1): 167
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  • Evaluation of patients with respiratory infections during the first pandemic wave in Germany: characteristics of COVID-19 versus non-COVID-19 patients #MMPMID33568104
  • Fink N; Rueckel J; Kaestle S; Schwarze V; Gresser E; Hoppe B; Rudolph J; Goller S; Kunz WG; Ricke J; Sabel BO
  • BMC Infect Dis 2021[Feb]; 21 (1): 167 PMID33568104show ga
  • BACKGROUND: Characteristics of COVID-19 patients have mainly been reported within confirmed COVID-19 cohorts. By analyzing patients with respiratory infections in the emergency department during the first pandemic wave, we aim to assess differences in the characteristics of COVID-19 vs. Non-COVID-19 patients. This is particularly important regarding the second COVID-19 wave and the approaching influenza season. METHODS: We prospectively included 219 patients with suspected COVID-19 who received radiological imaging and RT-PCR for SARS-CoV-2. Demographic, clinical and laboratory parameters as well as RT-PCR results were used for subgroup analysis. Imaging data were reassessed using the following scoring system: 0 - not typical, 1 - possible, 2 - highly suspicious for COVID-19. RESULTS: COVID-19 was diagnosed in 72 (32,9%) patients. In three of them (4,2%) the initial RT-PCR was negative while initial CT scan revealed pneumonic findings. 111 (50,7%) patients, 61 of them (55,0%) COVID-19 positive, had evidence of pneumonia. Patients with COVID-19 pneumonia showed higher body temperature (37,7 +/- 0,1 vs. 37,1 +/- 0,1 degrees C; p = 0.0001) and LDH values (386,3 +/- 27,1 vs. 310,4 +/- 17,5 U/l; p = 0.012) as well as lower leukocytes (7,6 +/- 0,5 vs. 10,1 +/- 0,6G/l; p = 0.0003) than patients with other pneumonia. Among abnormal CT findings in COVID-19 patients, 57 (93,4%) were evaluated as highly suspicious or possible for COVID-19. In patients with negative RT-PCR and pneumonia, another third was evaluated as highly suspicious or possible for COVID-19 (14 out of 50; 28,0%). The sensitivity in the detection of patients requiring isolation was higher with initial chest CT than with initial RT-PCR (90,4% vs. 79,5%). CONCLUSIONS: COVID-19 patients show typical clinical, laboratory and imaging parameters which enable a sensitive detection of patients who demand isolation measures due to COVID-19.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19/*diagnosis/epidemiology/*physiopathology[MESH]
  • |Emergency Service, Hospital[MESH]
  • |Female[MESH]
  • |Germany/epidemiology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Prospective Studies[MESH]
  • |Respiratory Tract Infections/*diagnosis/epidemiology/*physiopathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed[MESH]


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