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10.1016/j.immuni.2021.01.008 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.01.008 33567252!7871825!33567252     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (2): 340-354.e6 Nephropedia Template TP {{tp|p=33567252|t=2021. COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses |pdf=|usr=}}{{33567252}} gab.com Text COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33567252 #FOAvip Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its relationship to antibodies, and pre-existing immunity against endemic coronaviruses (huCoV), which has been hypothesized to be protective, were investigated in 82 healthy donors (HDs), 204 recovered (RCs), and 92 active COVID-19 patients (ACs). ACs had high amounts of anti-SARS-CoV-2 nucleocapsid and spike IgG but lymphopenia and overall reduced antiviral T cell responses due to the inflammatory milieu, expression of inhibitory molecules (PD-1, Tim-3) as well as effector caspase-3, -7, and -8 activity in T cells. SARS-CoV-2-specific T cell immunity conferred by polyfunctional, mainly interferon-gamma-secreting CD4(+) T cells remained stable throughout convalescence, whereas humoral responses declined. Immune responses toward huCoV in RCs with mild disease and strong cellular SARS-CoV-2 T cell reactivity imply a protective role of pre-existing immunity against huCoV. Twit Text FOAVip COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=33567252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33567252 #FOAvip English Wikipedia <ref>{{Cite pmid|33567252}}</ref> COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses #MMPMID33567252 Bonifacius A; Tischer-Zimmermann S; Dragon AC; Gussarow D; Vogel A; Krettek U; Godecke N; Yilmaz M; Kraft ARM; Hoeper MM; Pink I; Schmidt JJ; Li Y; Welte T; Maecker-Kolhoff B; Martens J; Berger MM; Lobenwein C; Stankov MV; Cornberg M; David S; Behrens GMN; Witzke O; Blasczyk R; Eiz-Vesper B Immunity 2021[Feb]; 54 (2): 340-354.e6 PMID33567252show ga Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its relationship to antibodies, and pre-existing immunity against endemic coronaviruses (huCoV), which has been hypothesized to be protective, were investigated in 82 healthy donors (HDs), 204 recovered (RCs), and 92 active COVID-19 patients (ACs). ACs had high amounts of anti-SARS-CoV-2 nucleocapsid and spike IgG but lymphopenia and overall reduced antiviral T cell responses due to the inflammatory milieu, expression of inhibitory molecules (PD-1, Tim-3) as well as effector caspase-3, -7, and -8 activity in T cells. SARS-CoV-2-specific T cell immunity conferred by polyfunctional, mainly interferon-gamma-secreting CD4(+) T cells remained stable throughout convalescence, whereas humoral responses declined. Immune responses toward huCoV in RCs with mild disease and strong cellular SARS-CoV-2 T cell reactivity imply a protective role of pre-existing immunity against huCoV. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/blood/immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Cellular/*immunology[MESH] |Immunity, Humoral/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology[MESH]COVID-19 immune signatures reveal stable antiviral T cell function des(epmc).pdf DeepDyve Pubget Overpricing