Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Rev+Peru+Med+Exp+Salud+Publica 2020 ; 37 (4): 746-754 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Transfusion de plasma convaleciente de pacientes con COVID-19 #MMPMID33566918
Galvan CA; Toribio-Dionicio C; Alvarez-Angeles M; Alama-Bazan O; Sanchez-Ramirez L
Rev Peru Med Exp Salud Publica 2020[Oct]; 37 (4): 746-754 PMID33566918show ga
There is currently no vaccine available and no specific medication against Coronavirus 2019 disease (COVID-19). The treatment is mainly based on support measures. In this context, several potentially useful therapies have been approved for use in clinical trials, such as convalescent plasma transfusion (CPT). PubMed was searched for studies on convalescent plasma and COVID-19, SARS or MERS. Studies on clinical efficacy in diseases caused by other coronaviruses (SARS-CoV and MERS-CoV) showed clinical improvement, increase of neutralizing antibodies, decreased mortality and absence of adverse events during and after treatment. We found 13 studies on this type of treatment used in patients with severe and critical COVID-19. Despite limitations regarding methodology, number of patients and the protocols for the analysis of donors' convalescent plasma, patients who received CPT showed clinical improvement, improvement of ventilatory patterns, resolution of lung injuries, decreased mortality, improvement of laboratory parameters, increase of neutralizing antibodies, decreased viral load and low frequency of adverse events.
Rev+Peru+Med+Exp+Salud+Publica 2020 ; 37 (4): 746-754
