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10.1002/iid3.404 http://scihub22266oqcxt.onion/10.1002/iid3.404 33566457!8014746!33566457     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immun+Inflamm+Dis 2021 ; 9 (2): 331-339 Nephropedia Template TP {{tp|p=33566457|t=2021. Age-related differences in the immune response could contribute to determine the spectrum of severity of COVID-19 |pdf=|usr=}}{{33566457}} gab.com Text Age-related differences in the immune response could contribute to determine the spectrum of severity of COVID-19 JO: Immun Inflamm Dis http://www.kidney.de/pget.php?&tw=1&pmid=33566457 #FOAvip Coronavirus disease 2019 (COVID-19), can present with a wide spectrum of severity. Elderly patients with cardiac, pulmonary and metabolic comorbidities are more likely to develop the severe manifestations of COVID-19, which are observed in less than 5% of the pediatric patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is able to induce an immune impairment and dysregulation, finally resulting in the massive release of inflammatory mediators, strongly contributing to the pulmonary and systemic manifestations in COVID-19. In children, the immune dysregulation following SARS-CoV-2 can also be responsible of a severe disease phenotype defined as multisystem inflammatory syndrome in children. As the immune system undergoes a complex process of maturation from birth to adult age, differences in the immune and inflammatory response could have a significant impact in determining the spectrum of severity of COVID-19. Indeed, children show a higher ability to respond to viral infections and a reduced baseline pro-inflammatory state compared with elderly patients. Age and comorbidities contribute to disease severity through immune-mediated mechanisms, since they are associated with a chronic increase of pro-inflammatory mediators, and cause an enhanced susceptibility to develop an immune dysregulation following SARS-CoV-2 infection. Also the expression of ACE2, the receptor of SARS-CoV-2, varies with age, and is linked to the immune and inflammatory response through a complex, and not completely elucidated, network. This paper reviews the peculiar immunopathogenic aspects of COVID-19, with a focus on the differences between adult and pediatric patients. Twit Text FOAVip Age-related differences in the immune response could contribute to determine the spectrum of severity of COVID-19 ????Immun Inflamm Dis http://www.kidney.de/pget.php?&tw=1&pmid=33566457 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33566457 #FOAvip English Wikipedia <ref>{{Cite pmid|33566457}}</ref> Age-related differences in the immune response could contribute to determine the spectrum of severity of COVID-19 #MMPMID33566457 Costagliola G; Spada E; Consolini R Immun Inflamm Dis 2021[Jun]; 9 (2): 331-339 PMID33566457show ga Coronavirus disease 2019 (COVID-19), can present with a wide spectrum of severity. Elderly patients with cardiac, pulmonary and metabolic comorbidities are more likely to develop the severe manifestations of COVID-19, which are observed in less than 5% of the pediatric patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is able to induce an immune impairment and dysregulation, finally resulting in the massive release of inflammatory mediators, strongly contributing to the pulmonary and systemic manifestations in COVID-19. In children, the immune dysregulation following SARS-CoV-2 can also be responsible of a severe disease phenotype defined as multisystem inflammatory syndrome in children. As the immune system undergoes a complex process of maturation from birth to adult age, differences in the immune and inflammatory response could have a significant impact in determining the spectrum of severity of COVID-19. Indeed, children show a higher ability to respond to viral infections and a reduced baseline pro-inflammatory state compared with elderly patients. Age and comorbidities contribute to disease severity through immune-mediated mechanisms, since they are associated with a chronic increase of pro-inflammatory mediators, and cause an enhanced susceptibility to develop an immune dysregulation following SARS-CoV-2 infection. Also the expression of ACE2, the receptor of SARS-CoV-2, varies with age, and is linked to the immune and inflammatory response through a complex, and not completely elucidated, network. This paper reviews the peculiar immunopathogenic aspects of COVID-19, with a focus on the differences between adult and pediatric patients. |*Age Factors[MESH] |*SARS-CoV-2[MESH] |Adaptive Immunity[MESH] |Adolescent[MESH] |Adult[MESH] |Age of Onset[MESH] |Aged[MESH] |Aging/*immunology[MESH] |Angiotensin-Converting Enzyme 2/biosynthesis[MESH] |COVID-19/etiology/*immunology[MESH] |Child[MESH] |Child, Preschool[MESH] |Comorbidity[MESH] |Cytokine Release Syndrome/etiology/immunology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Infant[MESH] |Inflammation/immunology[MESH] |Lymphocyte Subsets/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Receptors, Virus/biosynthesis[MESH] |Severity of Illness Index[MESH] |Systemic Inflammatory Response Syndrome/etiology/immunology[MESH]Age-related differences in the immune response could contribute to det(epmc).pdf DeepDyve Pubget Overpricing