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10.1007/s10126-021-10020-z

http://scihub22266oqcxt.onion/10.1007/s10126-021-10020-z
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suck abstract from ncbi


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pmid33566210      Mar+Biotechnol+(NY) 2021 ; 23 (1): 149-155
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  • Photosynthetically Controlled Spirulina, but Not Solar Spirulina, Inhibits TNF-alpha Secretion: Potential Implications for COVID-19-Related Cytokine Storm Therapy #MMPMID33566210
  • Tzachor A; Rozen O; Khatib S; Jensen S; Avni D
  • Mar Biotechnol (NY) 2021[Feb]; 23 (1): 149-155 PMID33566210show ga
  • An array of infections, including the novel coronavirus (SARS-CoV-2), trigger macrophage activation syndrome (MAS) and subsequently hypercytokinemia, commonly referred to as a cytokine storm (CS). It is postulated that CS is mainly responsible for critical COVID-19 cases, including acute respiratory distress syndrome (ARDS). Recognizing the therapeutic potential of Spirulina blue-green algae (Arthrospira platensis), in this in vitro stimulation study, LPS-activated macrophages and monocytes were treated with aqueous extracts of Spirulina, cultivated in either natural or controlled light conditions. We report that an extract of photosynthetically controlled Spirulina (LED Spirulina), at a concentration of 0.1 microg/mL, decreases macrophage and monocyte-induced TNF-alpha secretion levels by over 70% and 40%, respectively. We propose prompt in vivo studies in animal models and human subjects to determine the putative effectiveness of a natural, algae-based treatment for viral CS and ARDS, and explore the potential of a novel anti-TNF-alpha therapy.
  • |COVID-19/*complications/*therapy[MESH]
  • |Cell Extracts/*pharmacology/*therapeutic use[MESH]
  • |Cells, Cultured[MESH]
  • |Cytokine Release Syndrome/*etiology/*therapy[MESH]
  • |Humans[MESH]
  • |In Vitro Techniques[MESH]
  • |Macrophages/*drug effects[MESH]
  • |Monocytes/*drug effects[MESH]


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