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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Ir+J+Med+Sci 2022 ; 191 (1): 1-5 Nephropedia Template TP
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There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia #MMPMID33564974
Williamson J; Black L; Black A; Koduri G; Kelly C
Ir J Med Sci 2022[Feb]; 191 (1): 1-5 PMID33564974show ga
INTRODUCTION: There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both. METHODS: This review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders. RESULTS: The therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this. DISCUSSION: We propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other.