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10.1186/s43088-021-00102-1 http://scihub22266oqcxt.onion/10.1186/s43088-021-00102-1 33564691!7861160!33564691     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33564691&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Beni+Suef+Univ+J+Basic+Appl+Sci 2021 ; 10 (1): 11 Nephropedia Template TP {{tp|p=33564691|t=2021. Mutational hotspots and conserved domains of SARS-CoV-2 genome in African population |pdf=|usr=}}{{33564691}} gab.com Text Mutational hotspots and conserved domains of SARS-CoV-2 genome in African population JO: Beni Suef Univ J Basic Appl Sci http://www.kidney.de/pget.php?&tw=1&pmid=33564691 #FOAvip BACKGROUND: Since outbreak in December 2019, the highly infectious and pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over a million deaths globally. With increasing burden, the novel coronavirus has posed a dire threat to public health, social interaction, and global economy. Mutations in the SARS-CoV-2 genome are moderately evolving which might have contributed to its genome variability, transmission, replication efficiency, and virulence in different regions of the world. RESULTS: The present study elucidated the mutational landscape in the SARS-CoV-2 genome among the African populace, which may have contributed to the virulence, spread, and pathogenicity observed in the region. A total of 3045 SARS-CoV-2 complete protein sequences with the reference viral sequence (EPI_ISL_402124) were mined and analyzed. SARS-CoV-2 ORF1ab, spike, ORF3, ORF8, and nucleocapsid proteins were observed as mutational hotspots in the African population and may be of keen interest in understanding the viral host relationship, while there is conservation in the ORF6, ORF7a, ORF7b, ORF10, envelope, and membrane proteins. CONCLUSIONS: The accumulation of moderate mutations (though slowly), in the SARS-CoV-2 genome as seen in this present study, could be a promising strategy to develop antiviral drugs or vaccines. These antiviral interventions should target viral conserved domains and host cellular proteins and/or receptors involved in viral invasion and replication to avoid a new viral wave due to drug resistance and vaccine evasion. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s43088-021-00102-1. Twit Text FOAVip Mutational hotspots and conserved domains of SARS-CoV-2 genome in African population ????Beni Suef Univ J Basic Appl Sci http://www.kidney.de/pget.php?&tw=1&pmid=33564691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33564691 #FOAvip English Wikipedia <ref>{{Cite pmid|33564691}}</ref> Mutational hotspots and conserved domains of SARS-CoV-2 genome in African population #MMPMID33564691 Omotoso OE; Babalola AD; Matareek A Beni Suef Univ J Basic Appl Sci 2021[]; 10 (1): 11 PMID33564691show ga BACKGROUND: Since outbreak in December 2019, the highly infectious and pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over a million deaths globally. With increasing burden, the novel coronavirus has posed a dire threat to public health, social interaction, and global economy. Mutations in the SARS-CoV-2 genome are moderately evolving which might have contributed to its genome variability, transmission, replication efficiency, and virulence in different regions of the world. RESULTS: The present study elucidated the mutational landscape in the SARS-CoV-2 genome among the African populace, which may have contributed to the virulence, spread, and pathogenicity observed in the region. A total of 3045 SARS-CoV-2 complete protein sequences with the reference viral sequence (EPI_ISL_402124) were mined and analyzed. SARS-CoV-2 ORF1ab, spike, ORF3, ORF8, and nucleocapsid proteins were observed as mutational hotspots in the African population and may be of keen interest in understanding the viral host relationship, while there is conservation in the ORF6, ORF7a, ORF7b, ORF10, envelope, and membrane proteins. CONCLUSIONS: The accumulation of moderate mutations (though slowly), in the SARS-CoV-2 genome as seen in this present study, could be a promising strategy to develop antiviral drugs or vaccines. These antiviral interventions should target viral conserved domains and host cellular proteins and/or receptors involved in viral invasion and replication to avoid a new viral wave due to drug resistance and vaccine evasion. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s43088-021-00102-1. äMutational hotspots and conserved domains of SARS-CoV-2 genome in Afri(epmc).pdf DeepDyve Pubget Overpricing