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10.1183/23120541.00741-2020 http://scihub22266oqcxt.onion/10.1183/23120541.00741-2020 33564671!7667727!33564671     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33564671&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       ERJ+Open+Res 2021 ; 7 (1): ? Nephropedia Template TP {{tp|p=33564671|t=2021. Heparin-binding protein levels correlate with aggravation and multiorgan damage in severe COVID-19 |pdf=|usr=}}{{33564671}} gab.com Text Heparin-binding protein levels correlate with aggravation and multiorgan damage in severe COVID-19 JO: ERJ Open Res http://www.kidney.de/pget.php?&tw=1&pmid=33564671 #FOAvip BACKGROUND: Critically ill coronavirus disease 2019 (COVID-19) patients may suffer persistent systemic inflammation and multiple organ failure, leading to a poor prognosis. RESEARCH QUESTION: To examine the relevance of the novel inflammatory factor heparin-binding protein (HBP) in critically ill COVID-19 patients, and evaluate the correlation of the biomarker with disease progression. STUDY DESIGN AND METHODS: 18 critically ill COVID-19 patients who suffered from respiratory failure and sepsis, including 12 cases who experienced a rapidly deteriorating clinical condition and six cases without deterioration, were investigated. They were compared with 15 age- and sex- matched COVID-19-negative patients with respiratory failure. Clinical data were collected and HBP levels were investigated. RESULTS: HBP was significantly increased in critically ill COVID-19 patients following disease aggravation and tracked with disease progression. HBP elevation preceded the clinical manifestations for up to 5 days and was closely correlated with patients' pulmonary ventilation and perfusion status. INTERPRETATION: HBP levels are associated with COVID-19 disease progression in critically ill patients. As a potential mediator of disease aggravation and multiple organ injuries that are triggered by continuing inflammation and oxygen deficits, HBP warrants further study as a disease biomarker and potential therapeutic target. Twit Text FOAVip Heparin-binding protein levels correlate with aggravation and multiorgan damage in severe COVID-19 ????ERJ Open Res http://www.kidney.de/pget.php?&tw=1&pmid=33564671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33564671 #FOAvip English Wikipedia <ref>{{Cite pmid|33564671}}</ref> Heparin-binding protein levels correlate with aggravation and multiorgan damage in severe COVID-19 #MMPMID33564671 Xue M; Zeng Y; Qu HQ; Zhang T; Li N; Huang H; Zheng P; Hu H; Zhou L; Duan Z; Zhang Y; Bao W; Tian LF; Hakonarson H; Zhong N; Zhang XD; Sun B ERJ Open Res 2021[Jan]; 7 (1): ? PMID33564671show ga BACKGROUND: Critically ill coronavirus disease 2019 (COVID-19) patients may suffer persistent systemic inflammation and multiple organ failure, leading to a poor prognosis. RESEARCH QUESTION: To examine the relevance of the novel inflammatory factor heparin-binding protein (HBP) in critically ill COVID-19 patients, and evaluate the correlation of the biomarker with disease progression. STUDY DESIGN AND METHODS: 18 critically ill COVID-19 patients who suffered from respiratory failure and sepsis, including 12 cases who experienced a rapidly deteriorating clinical condition and six cases without deterioration, were investigated. They were compared with 15 age- and sex- matched COVID-19-negative patients with respiratory failure. Clinical data were collected and HBP levels were investigated. RESULTS: HBP was significantly increased in critically ill COVID-19 patients following disease aggravation and tracked with disease progression. HBP elevation preceded the clinical manifestations for up to 5 days and was closely correlated with patients' pulmonary ventilation and perfusion status. INTERPRETATION: HBP levels are associated with COVID-19 disease progression in critically ill patients. As a potential mediator of disease aggravation and multiple organ injuries that are triggered by continuing inflammation and oxygen deficits, HBP warrants further study as a disease biomarker and potential therapeutic target. ?Heparin-binding protein levels correlate with aggravation and multiorg(epmc).pdf DeepDyve Pubget Overpricing