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10.17179/excli2020-3215 http://scihub22266oqcxt.onion/10.17179/excli2020-3215 33564281!7868638!33564281     free     free     free       EXCLI+J 2021 ; 20 (ä): 117-125 Nephropedia Template TP {{tp|p=33564281|t=2021. Unraveled roles of hyaluronan in severe COVID-19 |pdf=|usr=}}{{33564281}} gab.com Text Unraveled roles of hyaluronan in severe COVID-19 JO: EXCLI J http://www.kidney.de/pget.php?&tw=1&pmid=33564281 #FOAvip Coronavirus disease 2019 (COVID-19) is a pandemic viral pneumonia caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). Most of the severe COVID-19 patients come up with trouble breathing, persistent pressure in the chest and developing to acute respiratory distress syndrome (ARDS) with a high mortality rate. Infected lung brings about uncontrolled inflammation followed by the fluid leakage and accumulation of extracellular matrix. Hyaluronan (HA) is an essential component of the extracellular matrix (ECM) and plays crucial roles in both biological and pathological states. It is also primarily located within the respiratory airways and is uprising during COVID-19 infection. Hitherto, the association between COVID-19 pathophysiology and HA is still unclear. Herein, we provide an overview of the pathophysiology of SARS-CoV-2 infection in conjunction with the involvement of HA and the diminution of HA for therapeutic potential of COVID-19. For severe patients, HA depletion may be beneficial for preventing ARDS while monitoring and managing HA level in lung may improve survival rate of patients. Twit Text FOAVip Unraveled roles of hyaluronan in severe COVID-19 ????EXCLI J http://www.kidney.de/pget.php?&tw=1&pmid=33564281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33564281 #FOAvip English Wikipedia <ref>{{Cite pmid|33564281}}</ref> Unraveled roles of hyaluronan in severe COVID-19 #MMPMID33564281 Ontong P; Prachayasittikul V EXCLI J 2021[]; 20 (ä): 117-125 PMID33564281show ga Coronavirus disease 2019 (COVID-19) is a pandemic viral pneumonia caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2). Most of the severe COVID-19 patients come up with trouble breathing, persistent pressure in the chest and developing to acute respiratory distress syndrome (ARDS) with a high mortality rate. Infected lung brings about uncontrolled inflammation followed by the fluid leakage and accumulation of extracellular matrix. Hyaluronan (HA) is an essential component of the extracellular matrix (ECM) and plays crucial roles in both biological and pathological states. It is also primarily located within the respiratory airways and is uprising during COVID-19 infection. Hitherto, the association between COVID-19 pathophysiology and HA is still unclear. Herein, we provide an overview of the pathophysiology of SARS-CoV-2 infection in conjunction with the involvement of HA and the diminution of HA for therapeutic potential of COVID-19. For severe patients, HA depletion may be beneficial for preventing ARDS while monitoring and managing HA level in lung may improve survival rate of patients. äUnraveled roles of hyaluronan in severe COVID-19 (epmc).pdf DeepDyve Pubget Overpricing