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10.1038/s41598-021-82956-0 http://scihub22266oqcxt.onion/10.1038/s41598-021-82956-0 33564056!7873263!33564056     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33564056&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 3359 Nephropedia Template TP {{tp|p=33564056|t=2021. Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources |pdf=|usr=}}{{33564056}} gab.com Text Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33564056 #FOAvip Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a "One Health" perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a "One Health" perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources. Twit Text FOAVip Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33564056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33564056 #FOAvip English Wikipedia <ref>{{Cite pmid|33564056}}</ref> Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources #MMPMID33564056 Bovo S; Schiavo G; Ribani A; Utzeri VJ; Taurisano V; Ballan M; Munoz M; Alves E; Araujo JP; Bozzi R; Charneca R; Di Palma F; Djurkin Kusec I; Etherington G; Fernandez AI; Garcia F; Garcia-Casco J; Karolyi D; Gallo M; Martins JM; Mercat MJ; Nunez Y; Quintanilla R; Radovic C; Razmaite V; Riquet J; Savic R; Skrlep M; Usai G; Zimmer C; Ovilo C; Fontanesi L Sci Rep 2021[Feb]; 11 (1): 3359 PMID33564056show ga Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a "One Health" perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a "One Health" perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources. |*Genetic Variation[MESH] |Angiotensin-Converting Enzyme 2/genetics[MESH] |Animals[MESH] |Breeding[MESH] |CD13 Antigens/genetics[MESH] |Coronavirus Infections/*genetics[MESH] |Dipeptidyl Peptidase 4/genetics[MESH] |Gene Frequency[MESH] |Genetics, Population[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Humans[MESH] |INDEL Mutation[MESH] |One Health[MESH] |Polymorphism, Single Nucleotide[MESH] |Receptors, Virus/genetics[MESH] |Serine Endopeptidases/genetics[MESH] |Sus scrofa/*genetics[MESH] |Swine[MESH]Describing variability in pig genes involved in coronavirus infections(epmc).pdf DeepDyve Pubget Overpricing