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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2021 ; 12 (1): 897 Nephropedia Template TP
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Lasting antibody and T cell responses to SARS-CoV-2 in COVID-19 patients three months after infection #MMPMID33563974
Jiang XL; Wang GL; Zhao XN; Yan FH; Yao L; Kou ZQ; Ji SX; Zhang XL; Li CB; Duan LJ; Li Y; Zhang YW; Duan Q; Wang TC; Li ET; Wei X; Wang QY; Wang XF; Sun WY; Gao YW; Kang DM; Zhang JY; Ma MJ
Nat Commun 2021[Feb]; 12 (1): 897 PMID33563974show ga
The dynamics, duration, and nature of immunity produced during SARS-CoV-2 infection are still unclear. Here, we longitudinally measured virus-neutralising antibody, specific antibodies against the spike (S) protein, receptor-binding domain (RBD), and the nucleoprotein (N) of SARS-CoV-2, as well as T cell responses, in 25 SARS-CoV-2-infected patients up to 121 days post-symptom onset (PSO). All patients seroconvert for IgG against N, S, or RBD, as well as IgM against RBD, and produce neutralising antibodies (NAb) by 14 days PSO, with the peak levels attained by 15-30 days PSO. Anti-SARS-CoV-2 IgG and NAb remain detectable and relatively stable 3-4 months PSO, whereas IgM antibody rapidly decay. Approximately 65% of patients have detectable SARS-CoV-2-specific CD4(+) or CD8(+) T cell responses 3-4 months PSO. Our results thus provide critical evidence that IgG, NAb, and T cell responses persist in the majority of patients for at least 3-4 months after infection.