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10.2174/0929867328666210204205726

http://scihub22266oqcxt.onion/10.2174/0929867328666210204205726
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33563150!ä!33563150

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suck abstract from ncbi


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pmid33563150      Curr+Med+Chem 2021 ; 28 (40): 8384-8391
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  • Targeting Viral RNA-Dependent RNA Polymerases as an Antiviral Therapy #MMPMID33563150
  • Miranda D; Sanchez DJ
  • Curr Med Chem 2021[]; 28 (40): 8384-8391 PMID33563150show ga
  • Progressive globalization of our society brings not only worldwide integration, it also increases and promotes our exposure to new viral pathogens with evident impacts on our global health. Especially with the emergence of SARS-CoV-2, our biomedical research infrastructure has never been more compelled to rapidly develop antiviral regimens that demonstrate improved efficacy against these pathogens. Here, we showcase 3 poignant antivirals against the lucrative target, RNA-dependent RNA polymerase (RdRP) of RNA viruses - a timely and relevant topic given the present efforts against COVID-19. While effective drug designs against RdRP are important, their benefit and potential as a standard of care truly relies on them standing out in well-designed clinical trials.
  • |*COVID-19[MESH]
  • |*RNA-Dependent RNA Polymerase[MESH]
  • |Antiviral Agents/pharmacology/therapeutic use[MESH]
  • |Drug Design[MESH]
  • |Humans[MESH]
  • |RNA, Viral[MESH]


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