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10.3390/vaccines9020134

http://scihub22266oqcxt.onion/10.3390/vaccines9020134
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33562203!7915550!33562203
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suck abstract from ncbi

pmid33562203      Vaccines+(Basel) 2021 ; 9 (2): ä
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  • HIV mRNA Vaccines-Progress and Future Paths #MMPMID33562203
  • Mu Z; Haynes BF; Cain DW
  • Vaccines (Basel) 2021[Feb]; 9 (2): ä PMID33562203show ga
  • The SARS-CoV-2 pandemic introduced the world to a new type of vaccine based on mRNA encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly, an mRNA-based vaccine relies on the host's cells to manufacture protein immunogens which, in turn, are targets for antibody and cytotoxic T cell responses. mRNA-based vaccines have been the subject of research for over three decades as a platform to protect against or treat a variety of cancers, amyloidosis and infectious diseases. In this review, we discuss mRNA-based approaches for the generation of prophylactic and therapeutic vaccines to HIV. We examine the special immunological hurdles for a vaccine to elicit broadly neutralizing antibodies and effective T cell responses to HIV. Lastly, we outline an mRNA-based HIV vaccination strategy based on the immunobiology of broadly neutralizing antibody development.
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